Results 111 to 120 of about 362,096 (260)

Incorporating environmental heterogeneity and observation effort to predict host distribution and viral spillover from a bat reservoir. [PDF]

open access: yesProc Biol Sci, 2023
Ribeiro R   +7 more
europepmc   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Spatial heterogeneity and woody species distribution in a Schinopsis balansae (Anacardiaceae) forest of the Southern Chaco, Argentina</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Revista de Biología Tropical</i>, 1998 </span><br><span class="r_content">El objeto de este trabajo es analizar la heterogeneidad espacial de un bosque de Schinopsis balansae ("Quebrachal") cerca de Vera (Santa Fe, Argentina) y establecer si hay correlación entre la distribución de las especies leñosas y los factores ...</span><br><span class="r_sub"><i>I. M Barberis, E. F. Pire, J. P. Lewis</i></span><br><small><a href="https://doaj.org/article/53d222b82db743d49bfb251f4c1ca428" target="_blank" rel="nofollow" title="doaj.org/article/53d222b82db743d49bfb251f4c1ca428">doaj</a> </small>   <br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70261" target="_blank" rel="nofollow">Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...</span><br><span class="r_sub"><i>Saeka Nishihara<span id="ma_5" style="display:none">, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_5')">+3 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70261?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70261?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_5" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70261" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70261'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70261)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_5')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70278" target="_blank" rel="nofollow">Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...</span><br><span class="r_sub"><i>Hitomi Soumiya<span id="ma_6" style="display:none">, Masatake Osawa, Hidefumi Fukumitsu</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_6')">+2 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70278?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70278?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_6" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70278" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70278'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70278)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_6')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70283" target="_blank" rel="nofollow">From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.</span><br><span class="r_sub"><i>Stanislava Martínková, Jan Trnka</i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70283?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70283?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_7" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70283" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70283'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70283)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_7')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70308" target="_blank" rel="nofollow">Evolution‐guided yeast complementation reveals functional differences in human PSPH variants</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...</span><br><span class="r_sub"><i>Mauricio Campa‐Álvarez<span id="ma_8" style="display:none">, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_8')">+6 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70308?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70308?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_8" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70308" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70308'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70308)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_8')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/2211-5463.70310" target="_blank" rel="nofollow">Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli</a> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>FEBS Open Bio, EarlyView.</i></span><br><span class="r_content">Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.</span><br><span class="r_sub"><i>Michael C. Newton‐Vesty<span id="ma_9" style="display:none">, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_9')">+13 more</a></small></i></span><br><small><a href="https://onlinelibrary.wiley.com/doi/10.1002/2211-5463.70310?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default" target="_blank" rel="nofollow" title="wiley.com/doi/10.1002/2211-5463.70310?mi=2or9o2m&af=R&AllField=environmental heterogeneity&ConceptID=15941&content=articlesChapters&target=default">wiley</a> </small>   <div id="more_9" style="display:none"><a href="/sci_redir.php?doi=10.1002%2F2211-5463.70310" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/2211-5463.70310'); alert('Copied the doi');">copy doi</a> <small>(10.1002/2211-5463.70310)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_9')">+1 more source</a></small><br></div><div class="r"><p class="r_title"><a href="https://doi.org/10.1002/ece3.9869" target="_blank" rel="nofollow">Geographic isolation and environmental heterogeneity contribute to genetic differentiation in <i>Cephalotaxus oliveri</i>.</a> <b><a href="https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10008294&blobtype=pdf" target="_blank" rel="nofollow">[PDF]</a></b> </p><span class="r_subtitle"><img src="/img/openaccess.ico" alt="open access: yes" title="open access: yes" width="16" height="16"><i>Ecol Evol</i>, 2023 </span><br><span class="r_sub"><i>Liu H<span id="ma_10" style="display:none">, Wang Z, Zhang Y, Li M, Wang T, Su Y.</span>   <small><a href="#" style="color:#808080;" onClick="return toggle_div(this, 'ma_10')">+5 more</a></small></i></span><br><small><a href="https://europepmc.org/article/MED/36919017#free-full-text" target="_blank" rel="nofollow" title="europepmc.org/article/MED/36919017#free-full-text">europepmc</a> </small>   <div id="more_10" style="display:none"><a href="/sci_redir.php?doi=10.1002%2Fece3.9869" target="_blank" rel="nofollow">openaccessbutton.org (pdf)</a><br><a href="javascript:navigator.clipboard.writeText('10.1002/ece3.9869'); alert('Copied the doi');">copy doi</a> <small>(10.1002/ece3.9869)</small><br></div><small><a href="#" onClick="return toggle_div(this, 'more_10')">+1 more source</a></small><br></div><div class="r"><div style="margin-bottom:2px;overflow:hidden"><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-15._life_on_land/" class="suggestion"onclick="show_loader();"><b>15. life on land</b></a><br/><a href="/q-13._climate_action/" class="suggestion"onclick="show_loader();"><b>13. climate action</b></a><br/><a href="/q-11._sustainability/" class="suggestion"onclick="show_loader();"><b>11. sustainability</b></a><br/></div><div style="display: inline-block; float: left; font-size: small; padding-right: 16px; margin-top: -1px; padding-bottom: 1px;"><a href="/q-animals/" class="suggestion"onclick="show_loader();"><b>animals</b></a><br/><a href="/q-genetic_variation/" class="suggestion"onclick="show_loader();"><b>genetic variation</b></a><br/><a href="/q-environment/" class="suggestion"onclick="show_loader();"><b>environment</b></a><br/></div><div style="display: inline-block; 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