Results 171 to 180 of about 5,915,013 (307)

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Fragmentation in heterogeneity-based research: what do we deal with when we deal with heterogeneity?

, 2011
A main assumption of the research in management is the existence of heterogeneity among firms. However, since the first adoption of heterogeneity concept, it has been applied in several managerial fields with different meanings and definitions.
A. Pellegrino, LANZA, ANDREA, G. Simone
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

An environmental type-recessiveness framework for the spatial coupling of environmental heterogeneity and ICH recessiveness in Guizhou's ethnic minority villages, China. [PDF]

PLoS One
Guo R, Yao A.
europepmc   +1 more source

Stratified genome-wide association analysis of type 2 diabetes reveals subgroups with genetic and environmental heterogeneity. [PDF]

Hum Mol Genet, 2023
Christiansen CE, Arathimos R, Pain O, Molokhia M, Bell JT, Lewis CM.   +5 more
europepmc   +1 more source

Aesthetical value of environmental heterogeneity

Throughout their lives, people are in constant contact with the natural environments that surrounds them. The aesthetic value of this environment has a great infuence on man's relationship with it.
Bufka, Ondřej
core  

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Environmental heterogeneity dominates the regulation of metabolites in ephemeral plants by the rhizosphere microbial community. [PDF]

Front Plant Sci
Heng Z, Jiang K, Wang Y, Wang C, Liu H, Zhang L.   +5 more
europepmc   +1 more source

Environmental heterogeneity determines beta diversity and species turnover for woody plants along an elevation gradient in subtropical forests of China. [PDF]

For Res (Fayettev), 2023
Jiang L, Zhang X, Zhu J, Wei X, Chen B, Liu J, Zheng S, He Z.   +7 more
europepmc   +1 more source