Results 131 to 140 of about 5,123,940 (303)

Evaluation of the Environmental Impact of Milk Quotas [PDF]

The aim of this study is to examine the environmental impacts of the different systems for allocation and transfer of milk quota under the Common Agricultural Policy (CAP) in individual Member States of the European Union (EU). In particular, it seeks to
Baldock, D., Bartley, J., Burrell, A.M., Colman, D., Hart, K., Pointereau, P., Silcock, P.   +6 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Environmental impact

A report on the evaluation of the environmental impact based on life cycle assessments (LCA) according to ISO 14040 /44.
Prutha Prashant Kulkarni, Parikshit N. Mahalle   +1 more
openaire   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

On the drivers of ice nucleating particle diurnal variability in Eastern Mediterranean clouds

npj Climate and Atmospheric Science
We report the drivers of spatiotemporal variability of ice nucleating particles (INPs) for mixed-phase orographic clouds (~−25 °C) in the Eastern Mediterranean.
Kunfeng Gao, Franziska Vogel, Romanos Foskinis, Stergios Vratolis, Maria I. Gini, Konstantinos Granakis, Olga Zografou, Prodromos Fetfatzis, Alexandros Papayannis, Ottmar Möhler, Konstantinos Eleftheriadis, Athanasios Nenes   +11 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

High-resolution climate projection dataset based on CMIP6 for Peru and Ecuador: BASD-CMIP6-PE

Scientific Data
Here, we present BASD-CMIP6-PE, a high-resolution (1d, 10 km) climate dataset for Peru and Ecuador based on the bias-adjusted and statistically downscaled CMIP6 climate projections of 10 GCMs. This dataset includes both historical simulations (1850–2014)
Carlos Antonio Fernandez-Palomino, Fred F. Hattermann, Valentina Krysanova, Fiorella Vega-Jácome, Christoph Menz, Stephanie Gleixner, Axel Bronstert   +6 more
doaj   +1 more source

Environmental legislation and the impact of lobbying activities [PDF]

The paper is concerned with effects of lobbying activities by political pressure groups that wish to affect environmental legislation. Two interest groups are considered, environmentalists on the one hand and a polluters' lobby on the other.
Bartsch, Elga, Rauscher, Michael, Thomas, Ingo   +2 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source