Results 61 to 70 of about 1,376,815 (268)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Investigation on True Stress-Strain Curves of Flat and Corner Regions of Cold-Formed Section Using 3D Digital Image Correlation Method

Advances in Civil Engineering, 2019
The true stress-strain curve is the critical method to describe the practical material mechanical performance and the essential precondition to develop the advanced numerical simulation.
Bo Xu, Junwu Xia, Renwei Ma, Jian Wang, Xiaomiao Chen, Hongfei Chang, Lihai Zhang   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Assessment of POPs in foods from western China: Machine learning insights into risk and contamination drivers

Environment International
Persistent organic pollutants (POPs), including PCDD/Fs, PCBs, and PBDEs, are major environmental and food safety concerns due to their bioaccumulative and toxic properties. However, comprehensive research on the concentrations and influencing factors of
Dasheng Lu, Yuanjie Lin, Sunyang Le, Yuhang Chen, Chao Feng, Zixin Qian, Guoquan Wang, Jingguang Li, Ping Xiao   +8 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A scalable method for identifying key indicators to assess urban environmental sustainability: A case study in Norway

City and Environment Interactions
Urbanization presents numerous societal challenges and exacerbates environmental issues. It is crucial to comprehend the current state and future direction of cities to formulate strategies and actions that mitigate negative consequences while ensuring a
Hai-Ying Liu, Babak Ebrahimi
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dealing with Culturally Sensitive Areas in Industrial Project Design

International Indigenous Policy Journal, 2012
Potential cultural impacts from proposed industrial developments can affect culturally sensitive areas that are important to Aboriginal peoples. These cultural impacts are important for legal, political, and moral reasons and can have a major influence ...
Alan Ehrlich
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source