Results 71 to 80 of about 13,095,443 (310)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Assessing CETA's Impact on Environmental Law

, 2016
Why Could the EU-Canada Comprehensive Free Trade Agreement Have an Impact on Environmental ...
Misonne, Delphine, Assessing CETA's Impact on Environmental Law   +1 more
core  

Investigation on True Stress-Strain Curves of Flat and Corner Regions of Cold-Formed Section Using 3D Digital Image Correlation Method

Advances in Civil Engineering, 2019
The true stress-strain curve is the critical method to describe the practical material mechanical performance and the essential precondition to develop the advanced numerical simulation.
Bo Xu, Junwu Xia, Renwei Ma, Jian Wang, Xiaomiao Chen, Hongfei Chang, Lihai Zhang   +6 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Impact Toolbox

The Impact Toolbox by the Evaluating Societal Impact project is a catalogue of tools and methods that helps university staff select resources for a structured approach to academic impact ambitions, activities and assessment.The collection draws upon a ...
Evaluating Societal Impact
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Environmental impact of Data Centers: a study of the sector with a focus on the initiatives adopted by Italian Data Centers

, 2023
reservedThe thesis is about the environmental impact of Data Centers. The first part focuses on the sector, on the characteristics and types of Data Centers and their lifecycle, in order to understand what causes their impact.
BONETTO, CHIARA
core  

Assessment of POPs in foods from western China: Machine learning insights into risk and contamination drivers

Environment International
Persistent organic pollutants (POPs), including PCDD/Fs, PCBs, and PBDEs, are major environmental and food safety concerns due to their bioaccumulative and toxic properties. However, comprehensive research on the concentrations and influencing factors of
Dasheng Lu, Yuanjie Lin, Sunyang Le, Yuhang Chen, Chao Feng, Zixin Qian, Guoquan Wang, Jingguang Li, Ping Xiao   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source