Results 111 to 120 of about 2,717,832 (296)

Key Components and Best Practices for Environmental Impact Assessments [PDF]

open access: yes, 2016
New and emerging activities pose risks to the conservation and sustainable development of ABNJ in the absence of prior assessment, and remain a significant gap under UNCLOS.
Duncan E. J. Currie
core  

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

Metagenomic profiling of microbial community, antibiotic resistance genes and co-occurrence pattern in megacity rail transit system

open access: yesHygiene and Environmental Health Advances
Megacity rail transit systems harbor a pivotal microbial ecosystem that serves as a reservoir for antibiotic resistance genes (ARGs), which is intricately linked to the urban dissemination of infectious diseases. Here, we conducted metagenomic sequencing
Xiaojing Li, Lijun Zhang, Jian Chen
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast

open access: yesEcotoxicology and Environmental Safety
Exposure to perfluorooctane sulfonate (PFOS) has been associated with lower bone density and the occurrence of osteoporosis in human studies, but the effects and mechanisms of PFOS induces bone loss is not well understood.
Liming Xue   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Mechanism of Growth Phase-Dependent Nanoplastic Bioaccumulation in Tetrahymena thermophila

open access: yesAntioxidants
Nanoplastics are ubiquitous in aquatic environments, and elucidating their bioaccumulation behavior is essential for assessing toxicity and trophic transfer risks.
Zhongquan Jiang   +8 more
doaj   +1 more source

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