Results 71 to 80 of about 431,544 (308)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Is cumulative fossil energy demand a useful indicator for the environmental performance of products?

, 2006
The appropriateness of the fossil Cumulative Energy Demand (CED) as an indicator for the environmental performance of products and processes is explored with a regression analysis between the environmental life-cycle impacts and fossil CEDs of 1218 ...
Meent, Dik van de, Rombouts, Linda J A, Hendriks, A Jan, Hellweg, S., Rombouts, L.J.A., Huijbregts, Mark A J, Fischknecht, R., Hellweg, Stefanie, Reijnders, Lucas, Meent, D. van de, van de Meent, D., Ragas, Ad M J, Struijs, J., Struijs, Jaap, Hendriks, A.J., Frischknecht, R., Reijnders, L., Huijbregts, M.A.J., Frischknecht, Rolf, Ragas, A.M.J.   +19 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Environmental indicators for the urban environment : a literature review

, 2000
A vast body of literature exists on the genesis and evolution of environmental indicators of all varieties. This document attempts to track the somewhat complicated progress of urban environmental indicators, where they are in usage and to what avail. It
Convery, Frank J., Pender, Anne, Dunne, Louise   +2 more
core  

Too good to be true: pitfalls of usingmean Ellenberg indicator values in vegetation analyses

, 2012
Question: Mean Ellenberg indicator values (EIVs) inherit information about compositional similarity, because during their calculation species abundances (or presence–absences) are used as weights.
Schaffers, A.P., Zeleny, D.
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Discussion paper

, 1993
The purpose of this document is to describe Agriculture Canada's (AC) environmental indicator development project and to provide guidance on the development of indicators of environmental sustainability in Canadian ...
Agriculture Canada Environmental Indicator Working Group
core  

Development and testing of a risk indexing framework to determine field-scale critical source areas of faecal bacteria on grassland. [PDF]

, 2009
This paper draws on lessons from a UK case study in the management of diffuse microbial pollution from grassland farm systems in the Taw catchment, south west England. We report on the development and preliminary testing of a field-scale faecal indicator
Oliver, D. M., Fish, R, Fish, R. D., Hodgson, Chris J, Heathwaite, A.L., Chadwick, D. R., Chadwick, Dave R, Hodgson, C. J., Fish, Rob D., Hodgson, C.J., Hodgson, Chris J., Oliver, David, Oliver, David M., Winter, Michael, Chadwick, Dave R., Heathwaite, A. L., Page, Trevor, Heathwaite, A Louise, Winter, M., Heathwaite, A. Louise, Oliver, D.M., Chadwick, D.R., Page, T.   +22 more
core   +1 more source