Results 41 to 50 of about 231,383 (284)
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Environmental Licensing as an Instrument for the Environmental Management of Brazilian Public Ports [PDF]
Sustainability, 2020 Port environmental management initiatives have not yet been properly implemented in Brazilian public ports, and when they exist, they are still very fragmented and are not based on techniques of planning or environmental management, but instead are only intended to answer the minimum requirements of the legal licensing process for construction and port
Rafael C. M. S. Braga +1 more
openaire +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Assessing environmental licensing guidelines for wind energy in Brazil: implications for biodiversity conservation [PDF]
Brazilian Journal of BiologyIn the global pursuit of energy security and climate change mitigation, wind energy is a key low-carbon energy source. Brazil ranks sixth in global wind energy generation, with high demand concentrated in the Northeast region.
R. F. Oliveira +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Environmental Standards under International Oligopoly [PDF]
We explore the effects of domestic environmental standards when a domestic firm and a foreign rival compete in the domestic market. We focus on a situation where the introduction of environmental standards forces the foreign product out of the domestic ...
Ishikawa, Jota, Okubo, Toshihiro
core +3 more sources
Desenvolvimento e Meio Ambiente, 2015 The implementation of the Petrochemical Complex of Rio de Janeiro – COMPERJ in the city of Itaboraí-RJ, tends to generate social and environmental impacts on the surrounding protected areas, within the Atlantic Forest Central Fluminense Mosaic (MCF ...
Breno Herrera da Silva Coelho +3 more
doaj +1 more source
Diversitas Journal, 2021 There is a need for a greater uderstanding of the relationships that are imbricated in Public Environmental Management (PEM), having as principle the Critical Enviromental Education, like an instrument of Federal Environmental ...
Mônica do Nascimento Brito +2 more
doaj +1 more source