Results 61 to 70 of about 232,478 (304)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

Gestão e licenciamento ambiental no Brasil: modelo de gestão focado na qualidade do meio ambiente

Cadernos EBAPE.BR
Com base na legislação ambiental, especialmente na Constituição Federal e nas Leis nº 6.938/81 e nº 9.433/97, este artigo aborda o gerenciamento ambiental no Brasil, particularmente quanto ao licenciamento ambiental e ao controle de atividades ...
Roberto Carrilho Padula, Luciene Pimentel da Silva   +1 more
doaj   +1 more source

THE HISTORICAL TRAJECTORY OF THE BELO MONTE HYDROELECTRIC PLANT'S ENVIRONMENTAL LICENSING PROCESS [PDF]

Ambiente & Sociedade, 2016
The purpose of this article is to present the historical trajectory of the hydroelectric plant of Belo Monte on the Xingu River. The plant, the third largest in the world and one of the most important works of the "Growth Acceleration Program" in Brazil,
MAÍRA BORGES FAINGUELERNT
doaj   +3 more sources

Cost Escalation in Nuclear Power [PDF]

, 1978
This report is concerned with the escalation of capital costs of nuclear central station power plants between the early 1960s and the present. The report presents an historical overview of the development of the nuclear power industry and cost escalation
Montgomery, W. David, Quirk, James P.
core  

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi, Mohanad A. Alkuwaiti, Yazeed B. Alaql, Ahmed K. Alsaif, Ahmed A. Alessa, Meshari Ayed Alharbi, Mohammed Alfalah, Saud A. Alnaaim, Sajjad M. AlHaddad, Ahmed Y. Azzam   +9 more
wiley   +1 more source

WEWENANG PEMERINTAH DAERAH DALAM PEMBERIAN IZIN LINGKUNGAN HIDUP

SASI, 2014
The results showed that local governments have the authority to give a license for environmental management based on the Chapter 237 Law Number 32 of 2004 Concerning the Local Government Jo Chapter 63 Law Number 32 of 2009 on Environmental Protection and
Vica J. E. Saija
doaj   +1 more source

THE EFFECTIVENESS OF ENVIRONMENTAL IMPACT ASSESSMENT SYSTEMS IN SÃO PAULO AND MINAS GERAIS STATES [PDF]

Ambiente & Sociedade, 2017
The effectiveness of the Environmental Impact Assessment (EIA) has been analyzed through the application of good practice criteria, with emphasis on assessing the quality of studies involved in it.
MARIA RITA RAIMUNDO E ALMEIDA, MARCELO MONTAÑO   +1 more
doaj   +3 more sources

Law, sex and the city: Regulating sexual entertainment venues in England and Wales [PDF]

, 2015
Purpose – This paper aims to explore how municipal law, in its various guises, serves to police the boundaries of acceptable sexual conduct by considering how Sexual Entertainment Venues (SEVs) in British cities are controlled through diverse techniques ...
Mr Luke Bennett, Professor Antonia Layard, Philip Hubbard   +1 more
core   +1 more source