Results 41 to 50 of about 4,776,540 (257)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Assessing environmental licensing guidelines for wind energy in Brazil: implications for biodiversity conservation [PDF]

Brazilian Journal of Biology
In the global pursuit of energy security and climate change mitigation, wind energy is a key low-carbon energy source. Brazil ranks sixth in global wind energy generation, with high demand concentrated in the Northeast region.
R. F. Oliveira, L. M. Diele-Viegas, M. A. Efe   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ENVIRONMENTAL LICENSING:

, 2020
The National Environment Policy, established by Law No. 6938 of 1981, aims at environmental preservation in line with the economic and social development of the country, establishing, therefore, the appropriate guidelines and instruments. These include environmental impact assessment and environmental licensing of effective or potentially potentially ...
Mello, Marcela Souza Zarske de, Vieira, Ricardo Stanziola   +1 more
openaire   +1 more source

Position statement on telemedicine/telehealth

, 2020
"Board approved January 9, 2019"--Unnumbered page 2; "Created: 1/10/2019..."--Document properties screenThough created and approved prior to the COVID-19 pandemic, this document was shared as part of the Ohio Veterinary Medical Licensing Board's response
Ohio Veterinary Medical Licensing Board
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Dampak Penyederhanaan Perizinan Lingkungan yang diatur oleh Undang-Undang No 11 Tahun 2020 Tentang Cipta Kerja Terhadap Lingkungan Hidup Masyarakat Serta Pelaku Usaha

Al-Adl
Sebagai hukum administrasi dengan sifatnya yang instrumental, maka fungsi yang menonjol dalam hukum lingkungan administratif adalah bersifat preventif berupa pencegahan terhadap pencemaran dan/atau kerusakan lingkungan.
Ricky Yuniardi, Yoyok Suharyanto, Agus Satory   +2 more
doaj   +1 more source

Conflitos entre o Comperj e a gestão de áreas protegidas: o Mosaico Central Fluminense como possibilidade de enfrentamento a impactos socioambientais de grandes empreendimentos industriais

Desenvolvimento e Meio Ambiente, 2015
The implementation of the Petrochemical Complex of Rio de Janeiro – COMPERJ in the city of Itaboraí-RJ, tends to generate social and environmental impacts on the surrounding protected areas, within the Atlantic Forest Central Fluminense Mosaic (MCF ...
Breno Herrera da Silva Coelho, Carlos Frederico Loureiro, Marta Azevedo Irving, David Gomes Soares   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source