Results 41 to 50 of about 50,016 (339)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Sedimentary Processes Within the Canadian Arctic Archipelago: Relationships Among Sedimentological, Geochemical, and Magnetic Sediment Properties

open access: yesGeochemistry, Geophysics, Geosystems, 2021
The sedimentological, geochemical, physical and magnetic properties of 40 surface and basal sediment samples of box cores collected throughout the Canadian Arctic Archipelago (CAA) from the Canadian Beaufort Shelf to Lancaster Sound were analyzed to ...
Sarah Letaïef   +2 more
doaj   +1 more source

Theory of Magnetic Edge States in Chiral Graphene Nanoribbons

open access: yes, 2011
Using a model Hamiltonian approach including electron-electron interactions, we systematically investigate the electronic structure and magnetic properties of chiral graphene nanoribbons.
Capaz, Rodrigo B.   +2 more
core   +1 more source

Paleomagnetism, rock magnetism and geochemical aspects of early Cretaceous basalts of the Paraná Magmatic Province, from Misiones, Argentina [PDF]

open access: yes, 2006
The basalts of the Posadas Formation were extruded during the huge continental volcanism that affected the Parana Basin in the Lower Cretaceous. We have carried out a paleomagnetic and rock-magnetic study on samples collected along a basalt outcrop ...
Lagorio, Silvia Leonor   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

A review of recent advances in red-clay environmental magnetism and paleoclimate history on the Chinese Loess Plateau

open access: yesFrontiers in Earth Science, 2016
The red-clay sequence on the Chinese Loess Plateau (CLP) was deposited during the late Miocene-Pliocene and is encoded with important information of past climate changes. However, it has received much less study in comparison to the overlying Pleistocene
Junsheng eNie, Yougui eSong, John eKing
doaj   +1 more source

Non‐Chained, Non‐Interacting, Stable Single‐Domain Magnetite Octahedra in Deep‐Sea Red Clay: A New Type of Magnetofossil?

open access: yesGeochemistry, Geophysics, Geosystems, 2021
Magnetic detection and classification of magnetofossils have been proposed as potential tools for paleoenvironmental studies. Magnetosomes in bacterial species living in different environmental conditions exhibit different grain morphologies and chain ...
Yoichi Usui, Toshitsugu Yamazaki
doaj   +1 more source

Sedimentary Iron Cycling and the Origin and Preservation of Magnetization in Platform Carbonate Muds, Andros Island, Bahamas [PDF]

open access: yes, 2007
Carbonate muds deposited on continental shelves are abundant and well-preserved throughout the geologic record because shelf strata are difficult to subduct and peritidal carbonate units often form thick, rheologically strong units that resist ...
Bosak, Tanja   +8 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

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