Results 151 to 160 of about 5,439,350 (296)

A Permutation Test-Based Approach to Strengthening Inference on the Effects of Environmental Mixtures: Comparison between Single-Index Analytic Methods. [PDF]

Environ Health Perspect, 2022
Day DB, Sathyanarayana S, LeWinn KZ, Karr CJ, Mason WA, Szpiro AA.   +5 more
europepmc   +1 more source

Mixture Effects of Environmental Contaminants

, 2015
Chemical exposure in humans rarely consists of a single chemical. The everyday exposure is characterized by thousands of chemicals mainly present at low levels. Despite that fact, risk assessment of chemicals is carried out on a chemical-by-chemical basis although there is a consensus that this view is too simplistic.
openaire   +1 more source

Drag Reduction of Complex Mixtures /

"Drag Reduction of Complex Mixtures discusses the concept of drag reduction phenomena in complex mixtures in internal and external flows that are shown experimentally by dividing flow patterns into three categories.
Watanabe, Keizo,author.
core  

Effect of Film Thickness on Resistance to Permanent Deformation in Asphalt Mixtures

, 2015
The resistance of asphalt mixtures against permanent deformation is one of important requirements that have to be verified in the design process of asphalt mixtures.
Eva Remišová, Remišová, Eva
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Estimating perinatal critical windows of susceptibility to environmental mixtures via structured Bayesian regression tree pairs. [PDF]

Biometrics, 2023
Mork D, Wilson A.
europepmc   +1 more source

Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures [electronic resource] /

, 2002
This document sets out the objectives, organisational context, and plan for a Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures.
Organisation for Economic Co-operation and Development., null null   +1 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments

生物医学转化
Humans are continuously exposed to large numbers of complex chemical mixtures at low doses in real-world environments, which may pose potential threats to health, particularly to reproductive and developmental health.
Cheng Qianhui, Li Sainan, Wang Linlin
doaj   +1 more source