Results 131 to 140 of about 5,439,350 (296)

IDENTIFYING THE SET OF SSD-EFFICIENT MIXTURES OF RISKY ALTERNATIVES [PDF]

Target MOTAD and other direct utility-maximization models provide one way of computing SSD-efficient mixtures. These models are appropriate when the utility function is known and can also be used to identify part of the set of SSD-efficient mixtures even
McCamley, Francis P., Kliebenstein, James B.   +1 more
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Keil et al. Respond to "Causal Inference for Environmental Mixtures". [PDF]

Am J Epidemiol, 2021
Keil AP, Buckley JP, Kalkbrenner AE.
europepmc   +1 more source

Effects of environmentally relevant mixtures of microplastics on soil organisms

Environmental Toxicology and Chemistry
Abstract Soil ecosystems are considered important sinks for microplastics (MPs). However, the effects of environmentally relevant mixtures of MPs on soil organisms have rarely been assessed. This study aimed to evaluate the chronic effects of a mixture of MPs on two model soil organisms, the earthworm Eisenia andrei and the springtail ...
Sara Martínez-Pérez, Theresa Schell, Daniel Franco, Sam van Loon, Paula E Redondo-Hasselerharm, Virtudes Martínez-Hernández, Cornelis A M van Gestel, Andreu Rico   +7 more
openaire   +2 more sources

Application of an extended bacterial toxicity assay to differentiate antibiotics from other contaminants in environmental mixtures

Human activities release a diversity of contaminants into the environment, including antibiotics. Bacterial toxicity assays are a useful tool to measure the sum toxicity of chemical contaminants in a water sample.
Tanveer, Rameesha, Neale, Peta A, Leusch, Frederic DL, Melvin, Steven D   +3 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Estimating the health effects of environmental mixtures using principal stratification. [PDF]

Stat Med, 2022
Peng RD, Liu JC, McCormack MC, Mickley LJ, Bell ML.   +4 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Erratum: "A Permutation Test-Based Approach to Strengthening Inference on the Effects of Environmental Mixtures: Comparison between Single-Index Analytic Methods". [PDF]

Environ Health Perspect, 2023
Day DB, Sathyanarayana S, LeWinn KZ, Karr CJ, Mason WA, Szpiro AA.   +5 more
europepmc   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source