Results 51 to 60 of about 676,874 (258)

Early warning monitoring and risk assessment on heavy metals in Shangba drinking water source in Nanjing

上海师范大学学报. 自然科学版, 2013
Heavy metal changes in Shangba drinking water source of Nanjing had been studied since the end of 2012 to the first of 2013, based on the analysis on continuous automatic monitoring data for Hg, As, Cu, Pb and Cd.
FU Yin, LIU Jun, CHEN Cheng, FANG Dong
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Research on the Precision Evaluation Standard for Determination of Zn in Soils

Yankuang ceshi, 2021
BACKGROUND The current technical specification, or standard method, to obtain the precision control level of a certain test item is to send the standard sample and a certain number of actual samples, with a known concentration level, to specific ...
LI Yu, TIAN Zhi-ren, JIANG Yue, XIA Xin
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dugong (Dugong dugon) Conservation in China: Current Status, Challenges, and Policy Recommendations

Conservation
The dugong (Dugong dugon) is the sole extant species of the genus Dugong within the order Sirenia, and the only strictly herbivorous marine mammal. As one of the oldest marine mammals, it plays a vital role in maintaining marine biodiversity.
Yue Zhang, Zhiguo Dou, Guoxiang Liao, Daoyan Xu, Shengjun Yan, Shifei Li   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Assessing Geomorphological Changes and Oil Extraction Impacts in Abandoned Yellow River Estuarine Tidal Flats Using Cloud Coverage in Region of Interest (CCROI) and WDM

Applied Sciences
Waterline extraction is a key step in applying the Waterline Detection Method (WDM) to Digital Elevation Model (DEM) generation. Cloud interference remains a major challenge for achieving high-quality extraction of waterlines.
Lianjie Zhang, Jishun Yan, Pan Zhang, Bo Zhao, Xia Lin, Quanming Wang   +5 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Polystyrene Nanoplastics Elicit Multiple Responses in Immune Cells of the Eisenia fetida (Savigny, 1826)

Toxics
The improper disposal of plastic products/wastes can lead to the release of nanoplastics (NPs) into environmental media, especially soil. Nevertheless, their toxicity mechanisms in soil invertebrates remain unclear.
Huijian Shi, Yaoyue Wang, Xiangxiang Li, Xiaoyang Wang, Yuntao Qi, Shaoyang Hu, Rutao Liu   +6 more
doaj   +1 more source