Results 71 to 80 of about 2,493,169 (277)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Disposable solid-contact ion-selective electrodes for environmental monitoring of lead with ppb [PDF]

, 2012
Solid-contact Pb2+-selective-electrodes and solid contact reference electrodes suitable for use as disposable sensing devices for environmental monitoring of lead have been prepared on screen-printed substrates.
Aleksandar Radu, Anastasova, Bakker, Bakker, Bakker, Bakker, Bakker, Benito-Lopez, Bobacka, Bobacka, Bobacka, Byrne, Cadogan, Carroll, Ceresa, Ceresa, Chernyshov, Claudio Zuliani, Dermot Diamond, Diamond, Diamond, Diamond, Diamond, Garcia-Cordero, Giusy Matzeu, Groenendaal, Heywang, Johan Bobacka, Kakiuchi, Lindner, Mattinen, Michalska, Radu, Radu, Renedo, Salzitsa Anastasova, Slaveykova, Sokalski, Sutter, Ulriika Mattinen, Vazquez   +40 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

The corresponding countermeasures of landslide risk control under influence of climate change in China

Geomatics, Natural Hazards & Risk
As one of the most landslide-prone countries, China is significantly affected by climate change worldwide. Understanding the influences of climate change on landslides and optimizing the corresponding countermeasures cannot be overstated. In this article,
Bin Tong, Yixiang Zhang, Gan Qi, Jusong Shi, Yuanqiang Wan, Jianyin He, Xudong Yang   +6 more
doaj   +1 more source

Annual report (first year). Project number: 7.ACP.RP.R. 578. April 2002 [PDF]

, 2002
This report is covering the first year of activity of the project. The on-going activities implemented along this first period and the variations with the work-plan are reported in the first chapter of the report.
Bourzat, Daniel, Maitima, Joseph, Nyabenge, Meshack, Reid, Robin   +3 more
core  

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Wastewater treatment plant inspection program, fiscal year 2006 and 2007 data report [PDF]

, 2008
This data report includes the results from Alachua County Environmental Protection Department’s inspections of wastewater treatment plants (WWTP) within Alachua County during the 2006 and 2007 fiscal years (October 2005 – September 2007).
Greco, Stacie
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source