Results 61 to 70 of about 2,466,142 (323)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Distribution and Long-Term Variation of Wetland Land Cover Types in the Yellow River Delta Remote Sensing Monitoring

Journal of Marine Science and Engineering
Wetlands are dubbed the “kidneys of the earth” and are involved in climate regulation, carbon sequestration, ecological balance preservation, and reducing the surface water pollution.
Chao Zhou, Qian Zhao, Tong Wu, Xulong Liu, Yanlong Chen   +4 more
doaj   +1 more source

Distribution Characteristics of Environmental Factors and Eutrophication Assessment in the Yancheng Coastal Areas

Haiyang Kaifa yu guanli, 2023
Spatial and temporal variations of nutrients and COD in the coastal waters of Yancheng coastal areas were studied based on three seasonal cruises during 2018.
Haihua XU, Yanzhe DING, Lihua LI, Yuheng ZHANG, Chengjuan CAO, Zhongwei CHEN, Lingxiao HANG, Xuyu ZHU   +7 more
doaj  

Editorial: Application of meta-omics in biotechnology, environmental monitoring, and health [PDF]

, 2023
Grace N. Ijoma
openalex   +1 more source

Ambient Rivers Monitoring in the Great Bay Estuary Watershed 2005 [PDF]

, 2006
The Department of Environmental Services (DES) received funding from the New Hampshire Estuaries Project (NHEP) to conduct monitoring activities in 2005.
Fardy, Stephanie, Landry, Natalie
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Annual report (first year). Project number: 7.ACP.RP.R. 578. April 2002 [PDF]

, 2002
This report is covering the first year of activity of the project. The on-going activities implemented along this first period and the variations with the work-plan are reported in the first chapter of the report.
Bourzat, Daniel, Maitima, Joseph, Nyabenge, Meshack, Reid, Robin   +3 more
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Polar Environmental Monitoring [PDF]

The present and projected benefits of the polar regions were reviewed and then translated into information needs in order to support the array of polar activities anticipated.
Nagler, R. G., Schulteis, A. C.
core   +1 more source