Results 111 to 120 of about 6,580,807 (306)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

FRESH: An Autonomous IoT Platform for Multi-Parameter Environmental Sensing and Short-Term Forecasting

Sensors
Environmental monitoring systems are often constrained by high cost, limited portability, restricted pollutant coverage, and dependence on fixed infrastructure, which can limit their suitability for distributed real-time sensing.
Feiling Pan, James A. Covington
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

On the role of pre and post-processing in environmental data mining [PDF]

, 2008
The quality of discovered knowledge is highly depending on data quality. Unfortunately real data use to contain noise, uncertainty, errors, redundancies or even irrelevant information.
Athanasiadis, Ioannis, Izquierdo, Joaquin, Holmes, Geoffrey, Comas, Joaquim, Gibert, Karina, Sanchez-Marre, Miquel   +5 more
core  

Calculation and Analysis of the Water Environment Capacity for the Typical Watershed in Liaoning Province

Shuitu baochi yanjiu, 2010
According to the one-dimensional and two-dimensional water quality model,the model of water environmental capacity was established.Under the comprehensive analysis of the water quality conditions,pollution sources of the typical watershed in Liaoning ...
ZHANG Fan, XU Jian-xin, XU Chen-guang
doaj  

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Bayesian Neural Network-Assisted Parameter Estimation of the Transmuted Teissier Distribution for Environmental Data Modeling

IEEE Access
Machine learning has evolved into a potent tool for analysing patterns and making predictions from complex data. In this machine learning era, we employed neural network techniques to estimate the parameters of statistical distributions.
P. T. Amrutha, C. S. Rajitha
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

ESTIMASI PARAMETER PADA STANDARD CAPM (CAPITAL ASSETS PRICING MODEL) DENGAN METODE GMM (GENERALIZED METHOD OF MOMENTS)

, 2014
Tujuan utama dari analisis regresi adalah menduga parameter yang tidak diketahui dalam model. Tiga metode estimasi populer yang banyak digunakan adalah kuadrat terkecil (Least-Squares) dan likelihood maksimum (Maximumum Likelihood) dan metode momen ...
ESTIMASI PARAMETER PADA STANDARD CAPM (CAPITAL ASSETS PRICING MODEL) DENGAN METODE GMM (GENERALIZED METHOD OF MOMENTS)
core