Results 111 to 120 of about 1,616,058 (308)

Checkpoint blockade and the stem‐like T cell trade‐off

Molecular Oncology, EarlyView.
Stem‐like T cells are key to the success of programmed cell death protein 1 (PD1) blockade, as they sustain long‐term anti‐tumor response by continuously generating effector CD8+ T cells. However, how these cells are maintained in cancer is not fully understood. Hor et al.
Julie M. Mazet, Johanna A. Joyce
wiley   +1 more source

Stochastic Dynamics of a Time-Delayed Ecosystem Driven by Poisson White Noise Excitation

Entropy, 2018
We investigate the stochastic dynamics of a prey-predator type ecosystem with time delay and the discrete random environmental fluctuations. In this model, the delay effect is represented by a time delay parameter and the effect of the environmental ...
Wantao Jia, Yong Xu, Dongxi Li
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

ELUCID IV: Galaxy Quenching and its Relation to Halo Mass, Environment, and Assembly Bias

, 2017
We examine the quenched fraction of central and satellite galaxies as a function of galaxy stellar mass, halo mass, and the matter density of their large scale environment.
Bosch, Frank C. van den, Chen, Sihan, Cui, Weiguang, Huang, Shuiyao, Jing, Yipeng, Kang, Xi, Li, Guoliang, Li, Shijie, Lim, S. H., Lin, Weipeng, Lu, Yi, Mo, H. J., Shi, Feng, Tweed, Dylan, Wang, Enci, Wang, Huiyuan, Wei, Chengliang, Yang, Xiaohu, Yang, Yang, Zhang, Youcai   +19 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Analysis of coal mine environment corrosion tendency based on fuzzy comprehensive evaluation method

Meitan kexue jishu
The coal mine environment is easy to cause corrosion damage to the anchorage material in long-term use because its complexity, which threatens the safety of roadway support.
Shuaiqian LI, Zhongping GUO, Zhuoyue WEN, Zhonghui XIE, Zhengtao HOU, Peng LI   +5 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Associating tornado occurrence with environmental parameters

Eos, Transactions American Geophysical Union, 2012
Tornado prediction on monthly scales could be improved if tornadoes could be associated with predictable environmental parameters. Tippett et al. sought to identify atmospheric parameters associated with monthly tornado activity to create an index that could provide a basis for extended‐range forecasts of monthly tornado activity.
openaire   +1 more source

Inverse Modelling, Sensitivity and Monte Carlo Analysis in R Using Package FME [PDF]

Mathematical simulation models are commonly applied to analyze experimental or environmental data and eventually to acquire predictive capabilities. Typically these models depend on poorly defined, unmeasurable parameters that need to be given a value ...
Karline Soetaert, Thomas Petzoldt
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source