Results 41 to 50 of about 7,584,010 (340)

Putting interactions on the map

open access: yeseLife, 2022
A method called functional connectivity mapping helps model some of the complex interactions between multiple ecosystem services.
César Augusto Ruiz Agudelo   +1 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Local authority provision of environmental planning guidelines for event management in Ireland

open access: yesEuropean Journal of Tourism Research, 2016
This paper discusses the environmental impacts generated by hosting events. More specifically it focuses on the case study of assessing the provision of environmental planning guidelines by Local Authorities to manage the environmental impacts of events ...
J. Hanrahan, K. Maguire
semanticscholar   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

GIS and remote sensing techniques to plan environmental linear parks [PDF]

open access: yesRevista Brasileira de Cartografia, 2006
In the linear parks bibliography most of the case studies show that park planning is done based on its history and particular attributes, without a methodology that can guide new projects.
Lucilia do Carmo Giordano   +1 more
doaj  

Promotion of Ecological Civilization Construction in the Pearl River Delta Region

open access: yes中国工程科学, 2022
Ecological civilization construction is a major national development strategy. Studying the empirical modes and promotion strategies of ecological civilization construction in economically developed regions is vital for leading the construction across ...
Wang Jinnan   +5 more
doaj   +1 more source

Climate Change: Implications for the Assumptions, Goals and Methods of Urban Environmental Planning

open access: yes, 2016
As a result of increasing awareness of the implications of global climate change, shifts are becoming necessary and apparent in the assumptions, concepts, goals and methods of urban environmental planning. This review will present the argument that these
K. Hill
semanticscholar   +1 more source

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