Results 121 to 130 of about 13,359,027 (313)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Pollution Characterization and Environmental Impact Evaluation of Atmospheric Intermediate Volatile Organic Compounds: A Review

Toxics
Atmospheric intermediate volatile organic compounds (IVOCs) are important precursors of secondary organic aerosols (SOAs), and in-depth research on them is crucial for atmospheric pollution control.
Yongxin Yan, Yan Nie, Xiaoshuai Gao, Xiaoyu Yan, Yuanyuan Ji, Junling Li, Hong Li   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Spatiotemporal Patterns and Driving Factors of Forest Vegetation Carbon Storage in Jiangxi Province, China (1990–2024): A Geographically Weighted Regression Approach

Remote Sensing
Forests, as the largest terrestrial carbon sink, play a critical role in mitigating climate change. Accurately estimating forest vegetation carbon storage and identifying its drivers are essential for evaluating regional carbon sink functions and ...
Yue Gong, Jiaqiang Du, Xiaoqian Zhu, Lijuan Li, Yushuo Li, Xiaoshan Liu, Jincao Han   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Non-targeted screening and characterization of organic pollutants in wastewater from an industrial park in China

Emerging Contaminants
Industrial parks are significant sources of complex water pollution, making it challenging to trace pollutant origins and ensure water quality. This study established a non-targeted screening workflow and compound persistence, mobility, and toxicity (PMT)
Xu Tan, Shanwei Sun, Song Hou, Linlin Wu, Yangwei Bai, Hongbo Xi, Jian Xu, Changsheng Guo   +7 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Advances and Challenges in Understanding Atmospheric Oxidizing Capacity in China: Insights from Chemical Mechanisms and Model Applications

Toxics
The ability of the atmosphere to convert primary pollutants into secondary pollutants through atmospheric oxidants is referred to as the atmospheric oxidizing capacity (AOC).
Peixuan Li, Yanqin Ren, Fang Bi, Fangyun Long, Junling Li, Haijie Zhang, Zhenhai Wu, Hong Li   +7 more
doaj   +1 more source

Environmental Risk Management [PDF]

Science, 1984
openaire   +2 more sources