Results 131 to 140 of about 13,359,027 (313)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Research on rural domestic sewage discharge, influencing factors and pollution loads in the Yangtze river basin

Scientific Reports
In this study, the characteristics of rural domestic wastewater discharge in the Yangtze River Basin, China, are analysed via geographic information visualization, pollutant load assessment, and correlation analysis.
Junchao Li, Lifang Wang, Zheng Liu, Ting Cao, Haiyang Lü, Yao Zhu, Xuhua Li   +6 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Simultaneous Wastewater Treatment and Resources Recovery by Forward Osmosis Coupled with Microbial Fuel Cell: A Review

Membranes
Osmotic microbial fuel cells (OsMFCs) with the abilities to simultaneously treat wastewater, produce clean water, and electricity provided a novel approach for the application of microbial fuel cell (MFC) and forward osmosis (FO).
Hengliang Zhang, Liang Duan, Shilong Li, Qiusheng Gao, Mingyue Li, Fei Xing, Yang Zhao   +6 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Hydrological Seasonality Drives DOM–Bacteria Interactions in the Rushan River Basin

Microorganisms
To unravel hydrological controls on dissolved organic matter (DOM)–microbe interactions in river ecosystems, this study integrated 3D excitation–emission matrix spectroscopy (3D-EEMs), parallel factor analysis (PARAFAC), and 16S rRNA sequencing to ...
Shanshan Zheng, Fan Feng, Dongping Liu, Feng Qian, Xiaolin Xie, Huibin Yu, Yonghui Song   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Nonlinear Responses of Vegetation and Soil Properties to Rock Desertification Gradients in Qingzhen, China

Land
Karst rock desertification is an extreme form of land degradation that poses a serious threat to regional ecological security and sustainable development in Southwest China.
Yufeng Lu, Yi Wang, Yanjun Chen, Ni Song, Qiuming Wang, Meng Liu, Xiao Guan   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source