Results 81 to 90 of about 502,413 (242)

An Isothermal Deoxyribozyme Sensor for Rapid Detection of Enteroviral RNA

Biosensors
Enteric viruses are a major cause of waterborne infections due to their high environmental stability and extremely low infectious dose. Current molecular diagnostic methods, while accurate, often depend on thermal cycling and centralized laboratory ...
Begüm Şaş, Anastasiia Dmitrievna Kirichenko, Marina Anatolyevna Kapitonova, Anna Vyacheslavovna Shabalina, Olga Ilyinichna Kanaeva, Tamer Mohammed El-Messery, Vladimir Georgievich Dedkov, Anna Sergeevna Dolgova   +7 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Comparative environmental RNA and DNA metabarcoding analysis of river algae and arthropods for ecological surveys and water quality assessment. [PDF]

Sci Rep, 2022
Miyata K, Inoue Y, Amano Y, Nishioka T, Nagaike T, Kawaguchi T, Morita O, Yamane M, Honda H.   +8 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

RNA silencing response in chloroplast-replicating viroid siRNA biogenesis in plants

Phytopathology Research
RNA silencing represents a cellular regulatory and defence mechanism in eukaryotes across kingdoms. In plants, a combined functionality of DCL2 and DCL3 is crucial for their synergistic defence against whilst DCL4 is required for nucleus-replicating ...
Pengcheng Zhang, Xinlian Zhang, Atef M. Mohamed, Leizhen Wang, José-Antonio Daròs, Shifang Li, Mahmut Tör, Yiguo Hong   +7 more
doaj   +1 more source

Staphylococcus aureus utilizes environmental RNA as a building material in specific polysaccharide-dependent biofilms. [PDF]

NPJ Biofilms Microbiomes, 2022
Chiba A, Seki M, Suzuki Y, Kinjo Y, Mizunoe Y, Sugimoto S.   +5 more
europepmc   +1 more source

Mapping Internally and Environmentally Stimulated RNA Foci Formation [PDF]

Biophysical Journal, 2021
Eitan S. Acks, Caitlin M. Davis
openaire   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Light intensity affects RNA silencing of a transgene in Nicotiana benthamiana plants

BMC Plant Biology, 2010
Background Expression of exogenous sequences in plants is often suppressed through one of the earliest described RNA silencing pathways, sense post-transcriptional gene silencing (S-PTGS).
Tsagris Mina, Kotsis Dimitrios, Vrettos Nicholas, Kotakis Christos, Kotzabasis Kiriakos, Kalantidis Kriton   +5 more
doaj   +1 more source

Synergistic action of the gut microbiota in environmental RNA interference in a leaf beetle. [PDF]

Microbiome, 2021
Xu L, Xu S, Sun L, Zhang Y, Luo J, Bock R, Zhang J.   +6 more
europepmc   +1 more source