Results 71 to 80 of about 7,694,143 (305)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

On-Farm Food Safety and Environmental Farm Plans: A Conceptual Framework for Identifying and Classifying Benefits and Costs [PDF]

open access: yes
This series of six reports entitled: "On-Farm Food Safety and Environmental Farm Plans: Identifying and Classifying Benefits and Costs" was initiated soon after the launch of the Agricultural Policy Framework (APF) in 2002.
Gervais, Jean-Philippe   +4 more
core  

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio   +8 more
wiley   +1 more source

The Cocktail Effects on the Acute Cytotoxicity of Pesticides and Pharmaceuticals Frequently Detected in the Environment

open access: yesToxics
Xenobiotics never appear as single, isolated substances in the environment but instead as multi-component mixtures. However, our understanding of the ecotoxicology of mixtures is far from sufficient. In this study, three active pharmaceutical ingredients
Balázs Göbölös   +7 more
doaj   +1 more source

Thermo-Catalytic Reforming of spent coffee grounds

open access: yesBioresources and Bioprocessing, 2019
Conversion of spent coffee grounds through the Thermo-Catalytic Reforming system (TCR®) is evaluated in this study. While, the TCR® is a technology that has been developed by Fraunhofer UMSICHT, which combines an intermediate pyrolysis and a catalytic ...
Mohamed Elmously   +4 more
doaj   +1 more source

Are Italians Willing to Pay for Agricultural Environmental Safety? A Stated Choice Approach [PDF]

open access: yes
The widespread use of pesticides in agriculture provides a particularly complex pattern of multidimensional negative side-effects, ranging from food safety related effects to the deterioration of farmland ecosystems.
Nijkamp, Peter, Travisi, Chiara M.
core  

Making the links among environmental protection, process safety, and industry 4.0

open access: yes, 2018
Industry 4.0 is an emerging concept in production systems and is described as a concept that encompasses technologies such as the Internet of Things, big data, cyber-physical systems, and smart objects.
Gobbo, Simone Cristina O. [UNESP]   +11 more
core   +1 more source

Risk of Non‐Arteritic Anterior Ischemic Optic Neuropathy in Idiopathic Intracranial Hypertension Patients Treated with GLP‐1 Receptor Agonists

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have demonstrated significant weight‐reducing effects and may offer benefits in idiopathic intracranial hypertension (IIH); however, recent concerns about the risk of non‐arteritic anterior ischemic optic neuropathy (NAION) have emerged.
Faisal A. Al‐Harbi   +9 more
wiley   +1 more source

Theoretical aspects of determining environmental security of the enterprise [PDF]

open access: yes
The concept of "environmental safety" is a synthesis of two concepts: "safety" and "ecology". As a rule, the concept of "ecology" is identified with the concept of "environment", and safety is identified with security.
Milka, Alla, Artyukh-Pasyuta, Olena
core  

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