Results 51 to 60 of about 7,694,143 (305)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Exposure and risk assessment for agricultural workers during chlorothalonil and flubendiamide treatments in pepper fields

Scientific Reports
Pesticides are indispensable tools in modern agriculture for enhancing crop productivity. However, the inherent toxicity of pesticides raises significant concerns regarding human exposure, particularly among agricultural workers.
Deuk-Yeong Lee, Jong-Wook Song, Ji-Young An, Yeong-Jin Kim, Jong-Su Seo, Jong-Hwan Kim   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Acute fish toxicity testing in pesticide risk assessment: still a necessary requirement for the future?

Environmental Sciences Europe
Background The reliance on traditional acute fish toxicity testing in the environmental risk assessment (ERA) of plant protection products (PPPs) raises ethical and scientific concerns, particularly considering the EU’s commitment to the 3Rs principle ...
Elena Adams, Sarah Hartmann, Daniel Faber, Yvonne Wolf, Markus Ebeling, Eric Bruns   +5 more
doaj   +1 more source

An evaluation of Aveda Corporation's environmental and safety management system (ESMS) orientation/inudction training in an ISO 14001 framework [PDF]

, 2004
Plan BThe purpose of this study was to evaluate the effectiveness of Aveda Corporation’s Environmental and Safety Management System (ESMS) Orientation/Induction training for manufacturing operations employees at the Blaine, MN facility.
Boysen, Stephanie Ann Van Dyke
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Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Quantitative Performance Analysis of Respiratory Facemasks Using Atmospheric and Laboratory Generated Aerosols Following with Gamma Sterilization

Aerosol and Air Quality Research, 2020
The emergence of the recent COVID-19 pandemic has rendered mandatory wearing of respiratory masks by infected persons, frontline workers, security personnel and members of the public.
Amit Kumar, D. N. Sangeetha, Ramani Yuvaraj, M. Menaka, Venkatesan Subramanian, Balasubramanian Venkatraman   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Multi-dimensional safety risk assessment on coal mines under the profitability dilemma

Scientific Reports, 2023
China is a major coal producer, with huge differences in coal production and safety situations between the South and the North. Taking province A as an example, its coal enterprises have low output, poor efficiency, backward equipment, and low-quality ...
Qi You, Qingguo Yao, Ruixin Song, Kai Yu, Cuicui Xu, Haiying Cao   +5 more
doaj   +1 more source

A Guide to the Texas Environmental, Health, and Safety Audit Privilege Act [PDF]

, 2013
Document with information about the Texas Environmental, Health, and Safety Audit Privilege Act (Audit Act) including the history of the act, significant changes made to the act in 1997 and 2013, and detailing the forms and procedures required by the ...
Texas Commission on Environmental Quality, Texas Commission on Environmental Quality. Litigation Division.   +1 more
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