Results 41 to 50 of about 1,462,954 (247)

Green corridor: A critical perspective and development of research agenda

Frontiers in Environmental Science, 2022
The rapid development of industrialization, transportation, and urbanization has a negative impact on nature such as increased pollution, decreased pervious surface area, and increased temperatures.
Aini Aman, Muhammad Rafiq, Omkar Dastane, Asrar Ahmed Sabir   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Fireflies produce ultrasonic clicks during flight as a potential aposematic anti-bat signal

iScience, 2021
Summary: Fireflies are known for emitting light signals for intraspecific communication. However, in doing so, they reveal themselves to many potential nocturnal predators from a large distance. Therefore, many fireflies evolved unpalatable compounds and
Ksenia Krivoruchko, Aya Goldshtein, Arjan Boonman, Ofri Eitan, Jonathan Ben-Simon, Vu Dinh Thong, Yossi Yovel   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Soil and Water Iron Microbes in North Carolina (SWIMNC) Outreach: Positive Impact of Combining Classroom and Field Experiences to Promote Learning and Shift Attitudes

Frontiers in Education, 2020
Environmental science is a topic that lends itself to innovative teaching methods in secondary education. Many aspects of environmental science have macroscopically observable components, creating myriad opportunities to link classroom lessons and ...
Megan Y. Andrews, Megan Y. Andrews, Andrew H. Whitaker, Tyler D. Sowers, Tyler D. Sowers, Owen W. Duckworth   +5 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Tropospheric Ozone: A Critical Review of the Literature on Emissions, Exposure, and Health Effects

Atmosphere
Tropospheric ozone is a significant air pollutant with severe adverse effects on human health. The complex dynamics of ozone formation, distribution, and health impacts underscore the need for a comprehensive understanding of this pollutant. Despite well-
Gabriele Donzelli, Maria Morales Suarez-Varela   +1 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source