Results 61 to 70 of about 1,462,954 (247)

How Can Humanities Interventions Promote Progress in the Environmental Sciences?

Humanities, 2017
Environmental humanists make compelling arguments about the importance of the environmental humanities (EH) for discovering new ways to conceptualize and address the urgent challenges of the environmental crisis now confronting the planet.
Sally L. Kitch
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hail as a damage vector for renewable energy

iScience
Summary: Hundreds of thousands of wind turbines and billions of solar photovoltaic (PV) panels are operating worldwide. Reliability, power production and operations, and maintenance costs for these electricity generation sources depend on operating ...
Sara C. Pryor, Rebecca J. Barthelmie
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Urban forest plant diversity affects soil organic carbon by regulating functional genes in Nanning

iScience
Summary: Urban forests serve as reservoirs of soil organic carbon (SOC) within ecosystems and play a critical role in the carbon (C) cycle. However, the regulatory mechanisms underlying SOC dynamics across urbanization gradients in urban forests remain ...
Wei Zhou, Zhao Wei, Ning Feng, Mi Luo, Bingpeng Qu, Qiren Luo, Jianbing Zhang   +6 more
doaj   +1 more source

Integrating Environmental Science and the Economy: Innovative Partnerships between the Private Sector and Research Infrastructures

Frontiers in Environmental Science, 2017
The present paper is a preliminary analysis of the funding, organizational culture, environmental, and innovation challenges that are currently faced by Environmental Research Infrastructures (ERI) and private enterprises working together.
Abad Chabbi, Abad Chabbi, Henry W. Loescher, Henry W. Loescher, Margaux S. Dillon   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Impact of mycotoxins and glyphosate residue on the gut microbiome and resistome of European fallow deer

iScience
Summary: Some mycotoxins and herbicide residues pose threats to animal health. These toxins might affect the gut microbiome of fallow deer. The analyzation of the intestinal content samples of this valuable game species exposed to varying levels of ...
Adrienn Gréta Tóth, Sára Ágnes Nagy, István Lakatos, Norbert Solymosi, Anikó Stágel, Melinda Paholcsek, Katalin Posta, Patrik Gömbös, Szilamér Ferenczi, Zsuzsanna Szőke   +9 more
doaj   +1 more source