Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Mapping large bodies of research in environmental sciences: insights from compiling evidence on the recovery and reuse of nutrients found in human excreta and domestic wastewater. [PDF]
Harder R.
europepmc +1 more source
Agency Curtailed: Implications for the Integration of Environmental Education in Life Sciences
Khathutshelo Ronald Munasi +1 more
openalex +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Threshold Concepts in Higher Education Physics as Identified by Students of Environmental Sciences
Paquita Perez +2 more
openalex +2 more sources
ILMIZI: Innovation Learning Model for Natural Science and Environmental Learning based on HOTS
Ilmi Zajuli Ichsan
openalex +2 more sources
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Maximizing the Impact of Research Featuring Nucleic-Acid Sequencing Methods in Environmental Science & Technology and Environmental Science & Technology Letters [PDF]
Alexandria B. Boehm +3 more
openalex +1 more source

