Results 151 to 160 of about 12,186,927 (332)
Earth benefits from NASA research and technology. Life sciences applications [PDF]
This document provides a representative sampling of examples of Earth benefits in life-sciences-related applications, primarily in the area of medicine and health care, but also in agricultural productivity, environmental monitoring and safety, and the ...
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, 2012 > Context • Society is faced with “wicked” problems of environmental sustainability, which are inherently multiperspectival, and there is a need for explicitly constructivist and perspectivist theories to address them.
Alrøe, Hugo Fjelsted, Noe, Egon
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Institutions in transition : reliability of rules and economic performance in former Socialist countries [PDF]
Building reliable institutions that support a market system is widely believed to be critical to a successful economic transition. The authors present indicators on the predictability of the institutional framework across twenty transition economies ...
Brunetti, Aymo +2 more
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Protocol for assessing neighborhood physical disorder using the YOLOv8 deep learning model
STAR ProtocolsSummary: Neighborhood physical disorder (PD), characterized by disruptions and irregularities in spatial elements, is associated with negative economic, social, and public health outcomes. Here, we present a protocol to quantitatively assess PD utilizing
Yan Li, Yue Ma, Ying Long
doaj +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Protocol for geographical mapping of pesticide contamination
STAR ProtocolsSummary: Pesticide residues in the environment threaten agricultural and human health. Here, we present a framework for mapping and comparing the contamination levels of pesticides across specific environmental compartments in various regions.
Yabi Huang, Zijian Li
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A modified truncated distribution for modeling the heavy tail, engineering and environmental sciences data. [PDF]
PLoS One, 2021 Gul A, Mohsin M, Adil M, Ali M.
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source