Results 151 to 160 of about 4,106,632 (313)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Microbial World: Recent Developments in Health, Agriculture and Environmental Sciences: An Annual Conference Organized by Association of Microbiologists of India and Indian Network for Soil Contamination Research. [PDF]

Indian J Microbiol, 2021
Dhingra GG, Saxena A, Nigam A, Hira P, Singhvi N, Anand S, Kaur J, Kaur J, Dua A, Negi V, Gupta V, Sood U, Kumar R, Lal S, Verma H, Verma M, Singh P, Rawat CD, Tripathi C, Talwar C, Nagar S, Mahato NK, Prakash O, Singh M, Kuhad RC, Singh Y, Lal B, Pabbi S, Singh N, Kalia VC, Lal R.   +30 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Protocol for low-cost quantification of microplastics through electrochemical impedance spectroscopy from aqueous matrices

STAR Protocols
Summary: We present a protocol to quantify microplastics (MPs) in aqueous matrices by analyzing the solution resistance (Rs) imparted by MPs using electrochemical impedance spectroscopy (EIS).
Almeenu Rasheed, Sovik Das
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Integrating the Concept of Sustainable Development into English Language Curriculum of Environmental Engineering Sciences [PDF]

, 2012
Rūta Petkutė
openalex   +1 more source

Gamification to Improve Participation in an Environmental Science Course: An Educator’s Reflection

, 2023
Kuok Ho Daniel Tang
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Measuring tourism and environmental sciences students' attitudes towards sustainable tourism. [PDF]

J Hosp Leis Sport Tour Educ, 2020
Arrobas F, Ferreira J, Brito-Henriques E, Fernandes A.   +3 more
europepmc   +1 more source

Science and environmental sustainability [PDF]

, 2016
Susan Owens
openalex   +1 more source