Results 91 to 100 of about 930,563 (304)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Environmental association modelling with loci under divergent selection predicts the distribution range of a lizard

, 2021
During the historical building of a species range, individual colonizers have to confront different ecological challenges, and the capacity of the species to broaden its range may depend on the total amount of adaptive genetic variation supplied by ...
Alejandro Llanos‐Garrido, Díaz González-Serrano, José Augusto, José A. Díaz, Llanos Garrido, Alejandro, Briega Álvarez, Andrea, Pérez Tris, Javier, Andrea Briega‐Álvarez, Javier Pérez‐Tris   +7 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Environmental contamination : a selection of papers presented at the 5th International Conference on Environmental Contamination, Morges, Switzerland, 29 September-1 October 1992 /

, 1993
This book deals with various aspects of environmental contamination. One of the fields considered in this work is atmospheric pollution. This has become a major problem of our time, and could soon develop into a scandal through the overestimation of the ...
Vernet, J.-P.(Jean-Pierre), International Conference on Environmental Contamination(5th :1992 :Morges, Switzerland)   +1 more
core  

Homogeneous environmental selection mainly determines the denitrifying bacterial community in intensive aquaculture water. [PDF]

Front Microbiol, 2023
Zheng X, Yan Z, Zhao C, He L, Lin Z, Liu M.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Data mining as a tool for environmental scientists

, 2006
Over recent years a huge library of data mining algorithms has been developed to tackle a variety of problems in fields such as medical imaging and network traffic analysis.
Athanasiadis, Ioannis, Letcher, Rebecca, Sànchez-Marrè, Miquel, Spate, Jessica, Frank, Eibe, Comas, Joaquim, Gibert, Karina   +6 more
core  

Application of value - focused thinking on the environmental selection of wall structures

, 2004
The decision of selecting building structures with respect to the environmental demand is an issue commonly addressed in environmental management. In this paper, the importance of considering the decision analysis technique value-focused thinking in the ...
Hassan, Osama A. B.,
core   +1 more source

Same habitat types but different use: evidence of context-dependent habitat selection in roe deer across populations

Scientific Reports, 2018
With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection.
Gaudry William, Gaillard Jean-Michel, Saïd Sonia, Bonenfant Christophe, Mysterud Atle, Morellet Nicolas, Pellerin Maryline, Calenge Clément   +7 more
doaj   +1 more source

Project external environmental factors affecting project delivery systems selection

Journal of Civil Engineering and Management, 2019
Project delivery systems (PDSs) selection is crucial to construction project management success. The matching between construction projects and PDSs is hypersensitive to project external environment.
Bingsheng Liu, Bin Xue, Tengfei Huo, Geoffrey Shen, Meiqing Fu   +4 more
doaj   +1 more source