Results 71 to 80 of about 930,563 (304)

Environmental selection of the cosmological constant and electroweak scales

Journal of High Energy Physics, 2022
We investigate whether selfish/Goldilocks Higgs models can be extended to accomodate vacua with both the right Higgs mass and cosmological constant. Through the introduction of multiple four-form fields coupled with the Higgs scalar boson we find that ...
Matteo Moretti, Francisco G. Pedro
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

WATERSHED SELECTION FOR ENVIRONMENTAL REHABILITATION USING MULTICRITERIA ANALYSIS

Ciência Florestal, 2009
The Anhumas creek watershed, in the region of Campinas, São Paulo State, Brazil, is degraded also as a result of unplanned land use of its riparian zones, considered Permanent Preservation Areas (APP).
Carlos Eduardo da Silva Francisco, Ricardo Marques Coelho, Roseli Buzanelli Torres, Samuel Fernando Adami   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

How Glyphosate and Its Derivatives Influence Antimicrobial Resistance Emergence and Transmission: A One Health Perspective

Antibiotics
Background/Objectives: Glyphosate-based formulations are globally pervasive pollutants increasingly recognized as potential contributors to antimicrobial resistance (AMR) in environmental microbiomes.
Leticia Malinoski, Gilmar Gonçalves Silva, Larissa Kaniak Ikeda Rodrigues, Leandro Flávio Carneiro, Marcelo Pedrosa Gomes   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

On the necessity of connectivity: linking key characteristics of environmental problems with governance modes [PDF]

, 2018
Environmental problems are often multi-faceted and complex by nature, consisting of diverse, intertwined dimensions. In this article, we argue that environmental problem characteristics have consequences for the selection of appropriate governance modes,
Driessen, P.P.J., Ingold, Karin, Driessen, Peter P.J., Widmer, Alexander, Runhaar, Hens A.C., Runhaar, Hens   +5 more
core   +1 more source

Selection for environmental variance of litter size in rabbits

Genetics Selection Evolution, 2017
Background In recent years, there has been an increasing interest in the genetic determination of environmental variance. In the case of litter size, environmental variance can be related to the capacity of animals to adapt to new environmental ...
Agustín Blasco, Marina Martínez-Álvaro, Maria-Luz García, Noelia Ibáñez-Escriche, María-José Argente   +4 more
doaj   +1 more source