Results 141 to 150 of about 930,563 (304)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Changes in environmental conditions regulate the biodiversity of planktonic microeukaryotes mediated by the dispersal-selection relationships in river: an example of the Beipan River, Guizhou, China

Frontiers in Microbiology
River planktonic microeukaryotes (phytoplankton and zooplankton) underpin aquatic ecosystem function, yet how environmental change regulates their biodiversity via assembly mechanisms remains poorly understood.
Xiaohan Dong, Xiaohan Dong, Jiaxin Huang, Jiaxin Huang, Xinxin Zhou, Xinxin Zhou, Jiali Ran, Jiali Ran, Ziwei Wang, Ziwei Wang, Zongqiang Qi, Zongqiang Qi, Yanjun Shen, Yanjun Shen, Yanjun Shen   +14 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Appropriate technology selection tool for decentralised wastewater treatment systems

, 2008
A transition toward decentralised treatment of wastewater is currently occurring in Australia and globally, giving the opportunity for a more sustainable water cycle.
Tomren, E., Anda, M., Ho, G.
core  

Selection and evolution of causally covarying traits

, 2014
The collection of the Soay sheep data is supported by the National Trust for Scotland and QinetQ, with funding from NERC, the Royal Society, and the Leverhulme Trust.When traits cause variation in fitness, the distribution of phenotype, weighted by ...
Morrissey, Michael Blair
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Bigger is Better: Avoided Deforestation Offsets in the Face of Adverse Selection

Voluntary opt-in programs to reduce emissions in unregulated sectors or countries have spurred considerable discussion. Since any regulator will make errors in predicting baselines and participants will self-select into the program, adverse selection ...
Kerr, Suzi, van Benthem, Arthur A.
core  

Erratum: Functional Traits and Spatio-Temporal Structure of a Major Group of Soil Protists (Rhizaria: Cercozoa) in a Temperate Grassland

Frontiers in Microbiology, 2019
Frontiers Production Office
doaj   +1 more source

Epigenetic Mechanisms Contribute to Evolutionary Adaptation of Gene Network Activity under Environmental Selection. [PDF]

Cell Rep, 2020
Luo X, Song R, Moreno DF, Ryu HY, Hochstrasser M, Acar M.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source