Results 171 to 180 of about 2,712,876 (308)

Coral tissue depth reconstructed using skeletal microstructural offsets is driven by environmental stress. [PDF]

Commun Earth Environ
Vincent J, Sheldrake T.
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Mild environmental stress inoculation promotes resilience to anxiety in female rats. [PDF]

Sci Rep
Mochizuki-Kawai H, Xiong T, Toyoshima M, Nakazawa S, Oike H, Kimoto H, Tomita S, Yamada K.   +7 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Redox-sensitive N⁶-methyladenosine RNA epitranscriptomic mechanisms in environmental stress and hazard. [PDF]

Redox Biol
Wāng Y.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Environmental Stress Shaping Oxidative Responses in the Invasive Crayfish <i>Procambarus clarkii</i> from Lake Trasimeno. [PDF]

Toxics
Caldaroni B, La Porta G, Dörr AJM, Gentile R, Futia S, Ludovisi A, Pallottini M, Selvaggi R, Bruschi F, Elia AC.   +9 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Elaborating the molecular characteristics of corals' different tolerance to environmental stress in Sanya Luhuitou based on multi-omics analysis. [PDF]

Front Microbiol
Tang X, Guo X, Wang H, Yang Q, Zhang Y, Ling J, Sun H, Dong J, Zhang Y.   +8 more
europepmc   +1 more source

The McCance Brain Care Score and Mortality: Evidence From a Large‐Scale Population‐Based Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives This study aimed to examine the relationship between the McCance Brain Care Score (BCS) and mortality in the general population. Methods We conducted a prospective, population‐based cohort study using data from the UK Biobank. Participants with complete data enabling calculation of BCS and full mortality information were included ...
Zhiqiang Xu, Xiaoxiao Wang, Nan Li
wiley   +1 more source