Results 41 to 50 of about 2,182,666 (262)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Bioclimatic Interior Architecture

open access: yesJournal of Architecture, Art & Humanistic Science
ingredients for civilized societies. And all sectors of society need it. Research Problem Research problem The research deals with one of the problems of internal architecture represented in ignoring the environmental dimension, which is reflected in ...
Assist.Prof. Dr. Shahenda Salah Abd El-Aziz Turk
doaj   +1 more source

Ecological stability and plasticity of potato varieties in Polissia

open access: yesPlant Varieties Studying and Protection, 2015
Purpose. Substantiating the selection of potato varieties for their ecological plasticity and stability to grow in Polissia. Methods. Field, laboratory, analitycal and statystical ones. Results.
Е. Р. Ермантраут   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Editorial: Editorial on Sustainability e-Journal

open access: yesSustainability: Science, Practice, & Policy, 2005
Open access will certainly make all those involved in the production, distribution, and consumption of science more aware of how interdependent they are.
E.O. Wilson
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Environmental Study of the Chromate Industry [PDF]

open access: yesOccupational and Environmental Medicine, 1951
Thepurpose ofthis paperistogive theresults ofanenvironmental study ofthethree chromate producing factories inGreatBritain investigated by Bidstrup (p. 302), andtocomparetheresults with those ofBourneandYee(1950) inasimilar study oftheindustry intheUnited States ofAmerica.
M, BUCKELL, D G, HARVEY
openaire   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Ferme gauloise et établissements ruraux gallo-romains du Bois de l’Homme Mort, Saint-Pathus (Seine-et-Marne) milieu iie s. av.-début ve ap. J.-C.

open access: yesRevue Archéologique du Centre de la France, 2011
Excavations at the Bois de l’Homme Mort locality, near the French village of Saint-Pathus, in northern Seine-et-Marne, have unveiled more than five centuries of rural antiquityA Gallic farm and three Gallo-Roman rural settlements, one of which could ...
Gilles Desrayaud
doaj  

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