Results 61 to 70 of about 673,787 (307)
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Design, crime and the built environment [PDF]
, 2017 Crime Prevention through Environmental Design (CPTED) is a method of reducing crime through the design and manipulation of the built environment. Based upon the Opportunity Theories of crime, CPTED focuses upon blocking opportunities for criminal ...
Armitage, Rachel
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
DiagnosticsDigital polymerase chain reaction (dPCR) has emerged as a groundbreaking technology in molecular biology and diagnostics, offering exceptional precision and sensitivity in nucleic acid detection and quantification.
Alessia Mirabile +8 more
doaj +1 more source
SurF: an innovative framework in biosecurity and animal health surveillance evaluation [PDF]
, 2018 Surveillance for biosecurity hazards is being conducted by the New Zealand Competent Authority, the Ministry for Primary Industries (MPI) to support New Zealand's biosecurity system.
Bingham, P +9 more
core +2 more sources
Environmental DNA for improved detection and environmental surveillance of schistosomiasis [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance Accurate detection and delineation of schistosomiasis transmission sites will be vital in ongoing efforts to control and ultimately eliminate one of the most neglected tropical parasitic diseases affecting >250 million people worldwide. Conventional methods to detect parasites in the environment are cumbersome and have
Mita E. Sengupta +11 more
openaire +5 more sources
Optimal environmental testing frequency for outbreak surveillance
Epidemics, 2023 AbstractPublic health surveillance for pathogens presents an optimization problem: we require enough sampling to identify intervention-triggering shifts in pathogen epidemiology, such as new introductions or sudden increases in prevalence, but not so much that costs due to surveillance itself outweigh those from pathogen-associated illness.
Jason W. Olejarz +4 more
openaire +3 more sources
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Frontiers in ParasitologyNeglected tropical diseases (NTDs) affect over a billion people worldwide. The 2021–2030 NTD road map calls for innovative and highly efficient interventions to eliminate or significantly reduce the burden of NTDs.
Juliet Hodgson +6 more
doaj +1 more source
Improving surveillance of emerging infectious diseases: ecological modelling of the spatial distribution of wild waterbirds to identify main areas of avian influenza viruses circulation in the Inner Niger Delta, Mali [PDF]
, 2010 Predicting areas of emergence when no epidemiological data is yet available is essential to implement efficient surveillance programs. The Inner Niger Delta (IND) in Mali is a major African wetlands where >1 million Palearctic and African waterbirds ...
Cappelle, Julien +4 more
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