Results 71 to 80 of about 1,485,059 (284)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Outdoor adventure education as a platform for developing environmental leadership

People and Nature
Notwithstanding actions taken to date through policy, programmes and practices, the planet remains on an unsustainable pathway. System level and individual actions are needed to address the challenges that confront us.
Garrett Hutson, Julia Baird, Christopher D. Ives, Gillian Dale, Jennifer M. Holzer, Ryan Plummer   +5 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Sustainability drivers, barriers and outcomes: Evidence from European High Performance Manufacturing Industries [PDF]

, 2015
Implementing sustainability practices has become a requirement to be able to operate in several markets since the legal requirements are increasing and society (as well as customers) values sustainability behaviors more. The aims of this paper are (1)
Domínguez Machuca, José Antonio, Miras Rodríguez, María del Mar   +1 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

BASS - Biodiversity Assessments at Small Scales [PDF]

Research Ideas and Outcomes
Much of the work developed on biodiversity dynamics due to climate change focuses on large scales. Yet, we know that small scale is critical to fully understand biodiversity change, particularly for plants and small or less mobile organisms which might ...
Fernando Ascensão, Pedro Cardoso, Rui Rebelo, Mário Boieiro, Alice Nunes, Sergio Chozas, Inês do Rosário, Adriana Príncipe, Cristina Máguas, Cristina Branquinho, Paulo Borges   +10 more
doaj   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

SEEA Revision: Accounting for Sustainability? [PDF]

The 1993 United Nations System for integrated Environmental and Economic Accounting (SEEA) aimed at measuring the - environmental - sustainability of economic performance and growth in terms of produced and natural capital maintenance.
Peter Bartelmus
core  

Sustainability appraisal: Jack of all trades, master of none? [PDF]

, 2009
Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development.
Alan J. Bond, Angus Morrison-Saunders, Ayre G., Bartlett R. V., Bekker M. P M, Bell S., Benson D., Bond A. J., Buckingham S., Cabeza Gutés M., Cherp A., Clark J., Clarke A. H., Dalal-Clayton B., Donnelly A., Donnelly A., Foxon T. J., Galobardes B., Gasparatos A., George C., Grey W., Hajer M. A., Jacob M., Kuhn T., Lawrence D. P., Leknes E., Luke T. W., Martin E. J., Mebratu D., Morrison-Saunders A., Morrison-Saunders A., Nykvist B., O'Riordan T., Owens S., Oxley T., Pope J., Pope J., Raina R. S., Ramos T. B., Redclift M. R., Russel D., Sankey H., Sheate W., Steinemann A., Svarstad H., Theobald W. F., Thérivel R., Thérivel R., Williams C. C., Wood C.   +49 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source