Results 191 to 200 of about 681,027 (341)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Potential of Subterranean Microbes: High-Throughput Screening for Industrially Relevant Enzymatic Activities in Dinaric Caves. [PDF]

Microbiologyopen
Babinskas J, Krutkevičius J, Lukić Bilela L, Bešta-Gajević R, Matijošytė I.   +4 more
europepmc   +1 more source

Random mutagenesis of human serine racemase reveals residues important for the enzymatic activity [PDF]

, 2010
Hillary E. Hoffman, Jana Jirásková, Marketa Zvelebil, Jan Konvalinka   +3 more
openalex   +1 more source

Enzymatic synthesis of vitexin glycosides and their activity

, 2022
Tingting Xu, Ziyun Fan, Junqiao Lou, Qi Du, Yue Kong, Yujia Lu, Xueming Wu   +6 more
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Class IIa HDACs Are Important Signal Transducers with Unclear Enzymatic Activities. [PDF]

Biomolecules
Brancolini C.
europepmc   +1 more source

Prior to versus after Metformin Treatment-Effects on Steroid Enzymatic Activities. [PDF]

Life (Basel), 2023
Gasser B, Escher G, Calin AE, Deppeler M, Marchon M, Mistry HD, Kurz J, Mohaupt MG.   +7 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Polypeptide encoded by the -1 PRF signal of SARS-CoV-2 controls multiple enzymatic activities of the viral NiRAN domain. [PDF]

NAR Mol Med
Hsu HT, Cho CP, Lin CL, Chang KY.
europepmc   +1 more source

Biomass and enzymatic activities of marine bacteria in the presence of multiple metals. [PDF]

Braz J Microbiol, 2023
Bitencourt JAP, Chequer LPT, Waite CC, Oliveira G, Oliveira AMS, Pereira DC, Crapez MAC.   +6 more
europepmc   +1 more source