Results 1 to 10 of about 1,215,842 (259)

Serum matrix metalloproteinase-9 levels and enzymatic activity in patients with anti-glomerular basement membrane disease [PDF]

Frontiers in Medicine
BackgroundAnti-glomerular basement membrane (anti-GBM) disease is an autoimmune disorder with autoantibodies against GBM component, non-collagenous domain of the α3 chain of type IV collagen, α3(IV)NC1. Matrix metalloproteinase-9 (MMP-9) is an endogenous
Huang Kuang, Huang Kuang, Huang Kuang, Huang Kuang, Hong-shan Wan, Hong-shan Wan, Hong-shan Wan, Hong-shan Wan, Qiu-hua Gu, Qiu-hua Gu, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia, Xiao-yu Jia, Zhao Cui, Zhao Cui, Zhao Cui, Zhao Cui, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao, Ming-hui Zhao   +21 more
doaj   +2 more sources

Staphylococcal Enterotoxin M Exhibits Thrombin-like Enzymatic Activity [PDF]

Biomolecules
To express and purify staphylococcal enterotoxin M (SEM) using immobilized metal affinity chromatography (IMAC), a signal peptide-truncated (ΔNsp) wild-type SEM (SEMWT) was N-terminally fused in pET-28a(+) to a polyhistidine tag (His6×-) and thrombin ...
Qian Huang, Shuang-Hua Luo, Wan-Fan Tian, Jun-Ni Tang, Ji Liu   +4 more
doaj   +2 more sources

Predicting Residual 21‐Hydroxylase Enzymatic Activity in Pediatric and Adult Congenital Adrenal Hyperplasia Patients: Towards Individualized Therapy [PDF]

CPT: Pharmacometrics & Systems Pharmacology
Congenital adrenal hyperplasia (CAH) is a genetic disorder characterized by impaired cortisol production and consequent elevated adrenocorticotropic hormone (ACTH): CAH patients often require lifelong hydrocortisone therapy.
Davide Bindellini, Robin Michelet, Yersultan Mirasbekov, Qizong Lao, Charles Sukin, Wilhelm Huisinga, Deborah P. Merke, Charlotte Kloft   +7 more
doaj   +2 more sources

Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies. [PDF]

J Enzyme Inhib Med Chem
Pirone L, Fiorillo B, Del Gatto A, Russo R, Guarracino A, Cassiano C, Zaccaro L, Moraca F, Pedone E, Catalanotti B.   +9 more
europepmc   +2 more sources

<i>De <i>N</i>ovo</i>-Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease. [PDF]

J Chem Inf Model
Lima TE, Moreira EG, Coêlho DF, Cruz CHB, Dhalia R, Leite BHS, Xavier LS, Illana MP, Wallau GL, Viana IFT, Lins RD.   +10 more
europepmc   +2 more sources

Selective Enzymatic Oxidation of Silanes to Silanols [PDF]

, 2020
Compared to the biological world's rich chemistry for functionalizing carbon, enzymatic transformations of the heavier homologue silicon are rare. We report that a wild‐type cytochrome P450 monooxygenase (P450_(BM3) from Bacillus megaterium, CYP102A1 ...
Dimitris E. Katsoulis, Frances H. Arnold, John M. Roberts, K. N. Houk, Marc Garcia‐Borràs, Sabine Brinkmann‐Chen, Susanne Bähr, Tumanskii B., Tumanskii B.   +8 more
core   +2 more sources

Efficient Biocatalytic Synthesis of Dihalogenated Purine Nucleoside Analogues Applying Thermodynamic Calculations [PDF]

, 2020
The enzymatic synthesis of nucleoside analogues has been shown to be a sustainable and efficient alternative to chemical synthesis routes. In this study, dihalogenated nucleoside analogues were produced by thermostable nucleoside phosphorylases in ...
Giessmann, Robert T., Kaspar, Felix, Klare, Hendrik F. T., Kurreck, Jens, Neubauer, Peter, Paulick, Katharina, Röhrs, Viola, Wagner, Anke, Westarp, Sarah, Yehia, Heba   +9 more
core   +1 more source

Chemical and biological reactions of solidification of peat using ordinary portland cement (OPC) and coal ashes [PDF]

, 2021
Construction over peat area have often posed a challenge to geotechnical engineers. After decades of study on peat stabilisation techniques, there are still no absolute formulation or guideline that have been established to handle this issue.
Abdul Rahman, Junita
core   +1 more source

Analysis of the Physicochemical Properties and Osteocyte Proliferative Activity of the Enzymatic Hydrolysis Products of Chinese Soft-shelled Turtle

Shipin gongye ke-ji, 2022
Alkaline protease, pepsin and trypsin were used to hydrolyze the bones and meat, shell and skirt of Chinese soft-shelled turtle to prepare functional peptides, and their physical and chemical properties such as main conformational changes and particle ...
Zexin LIN, Meilian YANG, Chao WU, Huagui HONG, Ming DU   +4 more
doaj   +1 more source

Enzymatic Preparation of Quinoa Protein Peptides and Its Lipid-lowering and Uric Acid-Lowering Activity in Vitro

Shipin gongye ke-ji, 2023
To study the optimal enzymatic hydrolysis conditions and uric acid-lowering activity of lipid-lowering peptides from quinoa protein, this study used quinoa as raw material to extract protein, and used pancreatic lipase inhibition rate as the activity ...
Wanying ZHONG, Jianyin MIAO, Haoduo YE, Feng MA, Yichen HU   +4 more
doaj   +1 more source