Results 31 to 40 of about 2,890,302 (318)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

Sesquiterpene synthases from Inonotus obliquus: functional characterization and β-farnesene production

Mycology
The medicinal mushroom Inonotus obliquus is renowned for producing a wide array of pharmacologically active terpenoids, yet the enzymatic basis for this diversity remains partially elusive.
Yingce Duan, Jiaxuan Liu, Zheyong Xue, Pengchao Wang, Jie Zhang, Chengwei Liu   +5 more
doaj   +1 more source

From sequence to enzyme mechanism using multi-label machine learning [PDF]

, 2014
Background: In this work we predict enzyme function at the level of chemical mechanism, providing a finer granularity of annotation than traditional Enzyme Commission (EC) classes.
De Ferrari, Luna; id_orcid, De Ferrari, L., John BO Mitchell, Luna De Ferrari, Mitchell, J.B O., Mitchell, John B O   +5 more
core   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

MACiE: a database of enzyme reaction mechanisms.

, 2005
SUMMARY: MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create
Gemma L. Holliday, Bartlett, G J, Noel M. O'Boyle, Janet M. Thornton, O'Boyle, N M, Peter Murray-Rust, John B. O. Mitchell, Holliday, G L, Almonacid, D E, Murray-Rust, P, Daniel E. Almonacid, Thornton, J M, Mitchell, John Blayney Owen, Gail J. Bartlett   +13 more
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Enzyme-enzyme co-abundance analysis.

, 2017
(a) Enzyme-enzyme co-abundance network. Nodes and edges indicate enzymes and their correlations. Positive (r > 0.6) and negative (r < -0.6) correlations were indicated as red and blue, respectively.
Atsumi Tomita (3797761), Shunsuke Nishino (2554585), Hiroshi Shimizu (76745), Fumio Matsuda (230101), Syohei Kinoshita (3797758)   +4 more
core   +1 more source

Enzyme-substrate interaction modeling strategies.

, 2022
(A) Current machine learning-directed evolution strategies, which involve design-build-test-model-learn cycles measuring protein variant activity on a single substrate of interest.
Samuel Goldman (1699888), Connor W. Coley (1496653), Ria Das (12072859), Kevin K. Yang (4528963)   +3 more
core   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Astroenzymology – the environmental limits of enzyme activity

, 2003
Using organisms from extreme terrestrial environments as models for extraterrestrial life may lead us to underestimate the range of environments that life may inhabit.
Daniel, Roy M., Roy Daniel
core   +1 more source