Results 101 to 110 of about 6,529,404 (392)

Optimal enzyme rhythms in cells [PDF]

arXiv, 2016
Cells can use periodic enzyme activities to adapt to periodic environments or existing internal rhythms and to establish metabolic cycles that schedule biochemical processes in time. A periodically changing allocation of the protein budget between reactions or pathways may increase the overall metabolic efficiency.
arxiv  

Oncogenic RET Kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans [PDF]

, 2014
To decipher the molecular basis for RET kinase activation and oncogenic deregulation, we defined the temporal sequence of RET autophosphorylation by label-free quantitative mass spectrometry.
Airaksinen, Annabel Borg, Arighi, Artim, Chan, Chen, Chen, Chen, Coulpier, Cutillas, DiNitto, Endres, Furdui, Gibelin, Hubbard, Hubbard, Iván Plaza-Menacho, Judith Murray-Rust, Karin Barnouin, Kawamoto, Kerry Goodman, Knowles, Lew, Lougheed, McTigue, Mologni, Neil Q. McDonald, Phillip Knowles, Plaza Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Plaza-Menacho, Rubén J. Martínez-Torres, Santoro, Stamos, Steen, Stephane Mouilleron, Wiesner, Yun, Zhang   +40 more
core   +1 more source

Crystal Structures of Salmonella typhimurium Biodegradative Threonine Deaminase and Its Complex with CMP Provide Structural Insights into Ligand-induced Oligomerization and Enzyme Activation*

Journal of Biological Chemistry, 2006
Two different pyridoxal 5′-phosphate-containing l-threonine deaminases (EC 4.3.1.19), biosynthetic and biodegradative, which catalyze the deamination of l-threonine to α-ketobutyrate, are present in Escherichia coli and Salmonella typhimurium ...
D. Simanshu, H. Savithri, M. Murthy
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Redox Biology, 2014
Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
doaj   +1 more source

Activation of thiamin diphosphate in enzymes [PDF]

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1998
Activation of the coenzyme ThDP was studied by measuring the kinetics of deprotonation at the C2 carbon of thiamin diphosphate in the enzymes pyruvate decarboxylase, transketolase, pyruvate dehydrogenase complex, pyruvate oxidase, in site-specific mutant enzymes and in enzyme complexes containing coenzyme analogues by proton/deuterium exchange detected
Hübner, Gerhard, Tittmann, Kai, Killenberg-Jabs, Margrit, Schäffner, Jörg, Spinka, Michael, Neef, Holger, Kern, Dorothee, Kern, Gunther, Schneider, Gunter, Wikner, Christer, Ghisla, Sandro   +10 more
openaire   +4 more sources

Identification of a novel 82 kDa proMMP-9 species associated with the surface of leukaemic cells [PDF]

, 2007
MMP-9 (matrix metalloproteinase 9) plays a critical role in tumour progression. Although the biochemical properties of the secreted form of proMMP-9 are well characterized, little is known about the function and activity of cell surface-associated proMMP-
Egea, Virginia, Jochum, Marianne, Mentele, Reinhard, Nagase, Hideaki, Pitsch, Thomas, Ries, Christian, Zahler, Stefan   +6 more
core   +1 more source

Calcium-dependent enzyme activation and vacuole formation in the apical granular region of pancreatic acinar cells.

Proceedings of the National Academy of Sciences of the United States of America, 2000
The pancreatic acinar cell produces powerful digestive enzymes packaged in zymogen granules in the apical pole. Ca(2+) signals elicited by acetylcholine or cholecystokinin (CCK) initiate enzyme secretion by exocytosis through the apical membrane ...
M. Raraty, J. Ward, G. Erdemli, C. Vaillant, J. Neoptolemos, R. Sutton, O. Petersen   +6 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Spin Cooperated Catalytic Activities in Mn-N4 based Single-atom Nanozyme: Mechanisms and a Brief Charge-spin Model [PDF]

arXiv, 2023
Although developing artificial enzymes has made great progress, there is still a gap between artificial enzymes and natural enzymes in catalytic performance. Designing and constructing efficient artificial biocatalysts is extremely desirable because of their high stability, low cost and easy storage.
arxiv