Results 71 to 80 of about 3,488,746 (297)

KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas. [PDF]

PLoS ONE, 2016
Lysine deacetylases (KDACs) are enzymes that reverse the post-translational modification of lysine acetylation. Recently, a series of N-acetylthioureas were synthesized and reported to enhance the activity of KDAC8 with a fluorogenic substrate.
Tasha B Toro, Subramanya Pingali, Thao P Nguyen, Destane S Garrett, Kyra A Dodson, Kyara A Nichols, Rashad A Haynes, Florastina Payton-Stewart, Terry J Watt   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Principal basis for enzyme power [PDF]

, 2008
The reaction rate enhancement that enzymes produce had not been fully appreciated. The object of the article is to present the mechanism of the enormous catalytic power of the enzymes.
Alexander G. Foigel
core  

Effect of activation energy microheterogeneity on first‐order enzyme deactivation

, 1987
The influence of microheterogeneity on enzyme inactivation kinetics is examined. A continuous normal distribution of the thermal activation energy is assumed, and using this, a simple mathematical model is developed to find the activity–time trajectories
Malhotra, Arun, Sadana, Ajit
core   +1 more source

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome [PDF]

, 2002
In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation
Dolmans, Wil M.V., Wil Dolmans, Setiati, T.E., Dolmans, W.M.V., C. Hack, Jos van der Meer, Hugo ten Cate, Hack, C. Erik, Hack, C.E., Djokomoeljanto, R.J., Cate, H. ten, Cate, Hugo ten, Suharti, C., Catharina Suharti, Djokomoeljanto, Robert J., Gorp, E. van, Meer, J.W.M. van der, Eric van Gorp, Napel, C.H.H. ten, Gorp , Eric C.M. van, Suharti, Catharina, Robert Djokomoeljanto, Gorp, E.C.M. van, Tatty Setiati, Meer, Jos W.M. van der, Setiati , Tatty E.   +25 more
core   +2 more sources

Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets. [PDF]

PLoS ONE, 2010
As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme.
Emilia Heimann, Helena A Jones, Svante Resjö, Vincent C Manganiello, Lena Stenson, Eva Degerman   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Determination of enzyme activities with the enzyme thermistor unit [PDF]

FEBS Letters, 1979
Practically all enzyrnic reactions can be followed by calorimetry. Important advantages of this technique are that the optical properties of the sample do not interfere with the measurements and that no auxiliary enzymic reactions are required such as those leading to changes in optical absorption that can be followed spectrophotometrically.
Danielsson, Bengt, Mosbach, Klaus
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Characterization of α- Amylase Produced from a Local Isolate of Bacillus licheniformis R5 [PDF]

Al-Qadisiyah Journal For Agriculture Sciences, 2016
This research is conducted at the College of Agriculture, University of Baghdad in 2004. The characterization of the purified enzyme shows that the molecular weight of the enzyme produced from the bacteria is 56.000 Daltons as it was determined by gel ...
Rana Abdullah Hussein, Mohammed O.Muhyaddin   +1 more
doaj   +1 more source