Results 61 to 70 of about 1,615,580 (309)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Development of catecholamine and cortisol stress responses in zebrafish. [PDF]
, 2014 Both adrenal catecholamines and steroids are known to be involved in the stress response, immune function, blood pressure and energy homeostasis. The response to stress is characterized by the activation of the hypothalamus-pituitary-adrenal (HPA) axis ...
Dipple, Katrina M +4 more
core +2 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Covalent immobilization of glucoamylase enzyme onto chemically activated surface of κ-carrageenan
Bulletin of the National Research Centre, 2019 Background Glucoamylase enzyme is one of the most important enzymes. It catalyzes the hydrolysis of starch into soluble sugars. It was covalently immobilized onto κ-carrageenan gel beads after activation by using polyethylenimine (PEI) followed by ...
Mohamed E. Hassan +2 more
doaj +1 more source
, 2015 We analyse the effect of intrinsic fluctuations on the properties of bistable stochastic systems with time scale separation operating under1 quasi-steady state conditions.
Fabian Spill +11 more
core +1 more source
Pattern formation at cellular membranes by phosphorylation and dephosphorylation of proteins [PDF]
, 2016 We consider a classical model on activation of proteins, based in two reciprocal enzymatic biochemical reactions. The combination of phosphorylation and dephosphorylation reactions of proteins is a well established mechanism for protein activation in ...
Alonso Muñoz, Sergio
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Recent Trends in Enzyme Inhibition and Activation in Drug Design
Molecules, 2020 It is known that enzymes are involved in many pathological conditions, such as inflammation, diabetes, microbial infections, HIV, neoplastic, neglected diseases and others [...]
Athina Geronikaki
doaj +1 more source
Can bio-inspired information processing steps be realized as synthetic biochemical processes?
, 2014 We consider possible designs and experimental realiza-tions in synthesized rather than naturally occurring bio-chemical systems of a selection of basic bio-inspired information processing steps.
Katz, Evgeny, Privman, Vladimir
core +1 more source
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. [PDF]
, 2013 Activation of the IκB kinase (IKK) is central to NF-κB signaling. However, the precise activation mechanism by which catalytic IKK subunits gain the ability to induce NF-κB transcriptional activity is not well understood.
Fusco, Amanda J +11 more
core +2 more sources