Results 251 to 260 of about 13,881,946 (357)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Insecticide resistance in Aedes aegypti and Aedes albopictus in southern Benin: quantification, investigation of kdr mutations, and detection of detoxification enzyme activity. [PDF]

Trop Med Health
Konkon AK, Aikpon R, Hoyochi I, Zoungbédji DM, Sovi A, Salako AS, Konkon C, Dangnon B, Yahoue G, Adjovi RV, Antoine L, Ahouandjinou J, Grace NK, Adjottin B, Baba-Moussa L, Osse R, Akogbéto M, Padonou GG.   +17 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Response of microbial structure characteristics and enzyme activity to different altitude. [PDF]

Front Microbiol
Cai QL, Jia GK, Wei C, Zhong N, Lv LL, Li J, Pang H, Yang W.   +7 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Data curation of extracellular enzyme activity spectrophotometric or fluorometric data. [PDF]

MethodsX
Christiansen NG, Iturbe-Espinoza P, Sapkota R, Winding A.   +3 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Effects of bacterial fertilizer and green manure on soil enzyme activity and root characteristics in Korla fragrant pear orchard. [PDF]

Front Microbiol
He Z, Li J, Yang L, Yan L, Chen B, Shen X, Chai Z.   +6 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA. [PDF]

Nat Commun
Hu M, Zhang B, Shan Y, Cao F, Wang Y, Qi W, Wang X, Shen Y, Guo X, Zhang M, Tian T, Xie W, Zhang M, Liang F, Pei D, Zhou X.   +15 more
europepmc   +1 more source