Results 261 to 270 of about 13,881,946 (357)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Altitudinal variation of soil extracellular enzyme activity in a subtropical evergreen broad-leaved forest. [PDF]

BMC Microbiol
Zhu D, Zhou Y, Hui D.
europepmc   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Catalytic Residue Reprogramming Enhances Enzyme Activity at Alkaline pH via Phenolate-Mediated Proton Transfer. [PDF]

ACS Synth Biol
Vajanapanich P, Nearmnala P, Parkbhorn J, Nutho B, Rungrotmongkol T, Hongdilokkul N.   +5 more
europepmc   +1 more source

The MMP‐9/TIMP‐1 Ratio and Concentrations of Osteopontin Are Elevated in Cerebrospinal Fluid of People With Multiple Sclerosis and Decrease After Autologous Hematopoietic Stem Cell Transplantation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To evaluate the utility of cerebrospinal fluid (CSF) biomarkers—matrix metalloproteinase‐9 (MMP‐9), tissue inhibitor of metalloproteinases‐1 (TIMP‐1), the MMP‐9/TIMP‐1 ratio, and osteopontin (OPN)—as indicators of blood–brain barrier (BBB) integrity and disease activity in people with relapsing–remitting multiple sclerosis (pwMS ...
Ivan Pavlovic, Ida Erngren, Kim Kultima, Anders Larsson, Malin Müller, Anna Wiberg, Joachim Burman   +6 more
wiley   +1 more source

Virulence factors of Candida spp. isolated from COVID-19 patients: hydrolytic enzyme activity and biofilm formation. [PDF]

BMC Microbiol
Jabrodini A, Yazdanpanah S, Malekzadeh M, Shabanzadeh S, Ahmadyan M, Pakshir K, Zomorodian K.   +6 more
europepmc   +1 more source

Effects of Different Drying Methods on the Quality of Forest Ginseng Revealed Based on Metabolomics and Enzyme Activity. [PDF]

Foods
Xing J, Li X, Dang W, Yang L, Zhang L, Li W, Zhao Y, Han J, Cai E.   +8 more
europepmc   +1 more source

Study on dynamic changes and correlations of microbial diversity, key enzyme activity and conventional components in tobacco leaves during the aging process. [PDF]

Bioresour Bioprocess
Cai W, Zhang QY, Zhu PC, Hu W, An H, Huo DQ, Li D.   +6 more
europepmc   +1 more source

Influence of Cutting Styles on Antioxidant Capabilities of Fresh-Cut Cauliflower by Regulating ROS Metabolism and Antioxidant Enzyme Activity. [PDF]

Antioxidants (Basel)
Guo Q, Li B, Wang J, Shi M, Wang J, Chen Y, Zhang Y, Sarengaowa, Xiao Y, Feng K.   +9 more
europepmc   +1 more source