Results 101 to 110 of about 4,824,034 (339)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Performance of commercially available anti-HDV enzyme-linked immunosorbent assays in Taiwan

Virology Journal, 2020
Background Hepatitis D virus (HDV) infection is a major global health issue around the world. There are approximately 15–20 million individuals infected with HDV worldwide.
Guan-Yu Lin, Yi-Le Wu, Cheng-Si Wang, Chia-Yun Ko, Chien-Hung Chen, Pei-Jer Chen, Po-Hsin Peng, Chao-Wei Hsu   +7 more
doaj   +1 more source

Functional Annotation, Genome Organization and Phylogeny of the Grapevine (Vitis vinifera) Terpene Synthase Gene Family Based on Genome Assembly, FLcDNA Cloning, and Enzyme Assays

BMC Plant Biology, 2010
BackgroundTerpenoids are among the most important constituents of grape flavour and wine bouquet, and serve as useful metabolite markers in viticulture and enology.
Diane M. Martin, S. Aubourg, Marina B Schouwey, Laurent Daviet, Michel Schalk, Omid Toub, Steven T. Lund, Jörg Bohlmann   +7 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]

, 2009
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang, Banumathy, Billy W. Day, Botha, Brian P. Mead, Chiu, Corinne Schneider, Craig, David A. Fidock, Donna M. Huryn, Ekland, Fernandez-Saiz, Fewell, Fewell, Fewell, Fidock, Frydman, Hartl, Hunt, Jeffrey L. Brodsky, Jiang, Juan-Carlos Valderramos, Maier, Matambo, Mayer, McClellan, McKerrow, Michael G. Klein, Midorikawa, Nadeau, Noedl, Pavithra, Pecoul, Peter Wipf, Raghavan Balachandran, Raj J. Chovatiya, Ramya, Rodina, Samantha L. Bell, Shonhai, Shonhai, Sidhu, Tang, Tonkin, Wellems, Werner, Wright, Xiaojiang S. Chen, Youker   +48 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Seroprevalence of toxoplasmosis in aborted women in Babylon Province, Iraq

Medical Journal of Babylon, 2019
Background: Toxoplasmosis is considered as one of the most prevalent human parasitic infections that can be transmitted from mother to the fetus. The onset of toxoplasmosis during pregnancy has clinical complications, including spontaneous abortion ...
Lawhedh Jasim Mohammed, Mohammed Salih Al-Janabi   +1 more
doaj   +1 more source

Direct replacement of antibodies with molecularly imprinted polymer (MIP) nanoparticles in ELISA - development of a novel assay for vancomycin [PDF]

, 2013
A simple and straightforward technique for coating microplate wells with molecularly imprinted polymer nanoparticles (nanoMIPs) to develop ELISA type assays is presented here for the first time.
Caygill, J. S., Chianella, Iva, Guerreiro, Antonio, Moczko, Ewa, Perez De Vargas Sansalvador, Isabel M., Piletska, Elena V., Piletsky, Sergey A., Whitcombe, Michael J.   +7 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source