Results 1 to 10 of about 1,716,016 (165)

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity [PDF]

eLife
Insulin degrading enzyme (IDE) is a dimeric M16A zinc metalloprotease that degrades amyloidogenic peptides diverse in shape and sequence, including insulin and amyloid-β, to prevent toxic amyloid fibril formation.
Jordan M Mancl, Wenguang G Liang, Nicholas L Bayhi, Hui Wei, William C Budell, Joshua H Mendez, Tobin R Sosnick, Bridget Carragher, Clinton S Potter, Wei-Jen Tang   +9 more
doaj   +2 more sources

Catalase Specifically Binds Antipsychotic Clozapine: Experimental and In Silico Insights into Interactions, Complex Stability, and Dose-Dependent Enzyme Activity Modulation [PDF]

Molecules
Oxidative stress is intrinsically linked to mental disorders, involving an imbalance between reactive species and antioxidant defenses, where catalase is an essential, ubiquitous antioxidant enzyme.
Tamara Vasović, Milica Radibratović, Dušan Spasić, Simeon Minić, Čedo Miljević, Nikola Gligorijević, Milan Nikolić   +6 more
doaj   +2 more sources

Peripheral blood mononuclear cell mitochondrial enzyme activity is associated with parity and lactation performance in early lactation Holstein dairy cows

Journal of Dairy Science, 2022
: Mitochondria are central to metabolism and are the primary energy producers for all biosynthesis, including lactation. The objectives of this study were to determine if high- and low-producing dairy cows exhibit differences in peripheral blood ...
A.M. Niesen, O.N. Genther-Schroeder, C.M.K. Bradley, J.A. Davidson, H.A. Rossow   +4 more
doaj   +1 more source

Production, Optimization and Partial Characterization of Alkaline Protease from Bacillus subtilis spp. subtilis NRRL B-3384 and B-3387

Hittite Journal of Science and Engineering, 2023
Bacillus subtilis has been a reliable platform for the expression of extracellular proteases for several decades. Although a majority of Bacillus subtilis subspecies express proteases, the amount of secreted enzyme varies depending on the strain and ...
Cengiz Akkale
doaj   +1 more source

The efficiency of indigenous isolates Bacillus sp. RCS1 and Bacillus cereus RCS3 on growth performance, blood biochemical indices and resistance against Vibrio harveyi in cobia fish (Rachycentron canadum) juveniles

Aquaculture Reports, 2022
In this study, cobia (Rachycentron canadum) juveniles were utilised as an aquatic model to explore growth performance and immune indices after 70 days of feeding with supplementation of viable isolated microbes’ concentrations of 1 × 1010 and 1 × 1012 ...
Eric Amenyogbe, Jian-dong Zhang, Jian-sheng Huang, Gang Chen   +3 more
doaj   +1 more source

Rational design of enzyme activity and enantioselectivity

Frontiers in Bioengineering and Biotechnology, 2023
The strategy of rational design to engineer enzymes is to predict the potential mutants based on the understanding of the relationships between protein structure and function, and subsequently introduce the mutations using the site-directed mutagenesis ...
Zhongdi Song, Qunfeng Zhang, Wenhui Wu, Zhongji Pu, Zhongji Pu, Haoran Yu, Haoran Yu   +6 more
doaj   +1 more source

Enzyme Producing Activity of Probiotics and Preparation of Compound Enzyme

Journal of Chemistry, 2020
Probiotics are a group of active microorganisms, which benefit the host by colonizing and changing the composition of host flora. It is of great significance to promote the development of human gastrointestinal nutrition and health by regulating the host
Ruokun Yi, Yanni Pan, Xingyao Long, Fang Tan, Xin Zhao   +4 more
doaj   +1 more source

Extraction, Purification and Characterization of Antioxidant Enzyme Catalase (CAT) Present in Chili (Capsicum annuum, Var. Azad Mirch-1) Plant [PDF]

Journal of Stress Physiology & Biochemistry, 2020
In this study, extraction, partial purification and characterization of an antioxidant enzyme catalase present in chilli (Capsicum annuum, var. Azad mirch-1) plant.
Saumya Katiyar, Anil Kumar
doaj  

Enzymatic activity of catechol 1,2-dioxygenase and catechol 2,3-dioxygenase produced by Gordonia polyisoprenivorans

Química Nova, 2012
This study aimed to evaluate the environmental conditions for enzyme activity of catechol 1,2-dioxygenase (C1,2O) and catechol 2,3-dioxygenase (C2,3O) produced by Gordonia polyisoprenivorans in cell-free and immobilized extracts.
Andréa Scaramal Silva, Flávio Anastácio de Oliveira Camargo, Robson Andreazza, Rodrigo Josemar Seminoti Jacques, Daiana Bortoluzzi Baldoni, Fátima M. Bento   +5 more
doaj   +1 more source

GENOTOXICITY AND ANTIOXIDANT ENZYME ACTIVITIES INDUCED BY THE CAPTAN FUNGICIDE IN THE ROOT OF BELL PEPPER (Capsicum annuum L. var. grossum L. cv. Kandil)

Trakya University Journal of Natural Sciences, 2019
In this study, we investigated the toxic effects of the captan fungicide by using morphological, physiological and cytological parameters in bell pepper (Capsicum annuum L. var. grossum L. cv. Kandil) root tissue. The seeds of bell pepper were germinated
Müge Saylan, Elif Yüzbaşıoğlu, Eda Dalyan, İlgin Akpınar, Muammer Unal   +4 more
doaj   +1 more source