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Trans-synaptic enzyme induction
Life Sciences, 1974Publisher Summary This chapter discusses the trans-synaptic enzyme induction. The increase in tyrosine hydroxylase synthesis is not a manifestation of a general increase in protein synthesis in the adrenergic neuron because under experimental conditions leading to a 2- to 3-fold increase in tyrosine hydroxylase activity, there was no detectable ...
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Induction of Detoxication Enzymes in Insects
Annual Review of Entomology, 1984Most of the known enzyme systems involved in the degradation of insecticides, other xenobiotics, and hormones of insects, appear to be inducible by various dietary chemicals, both plant-based and man-made. Although the understanding of the mechanism of this phenomenon comes almost entirely from studies of higher animals, there are good reasons to ...
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An outline of enzyme induction
Recueil des Travaux Chimiques des Pays-Bas, 1958AbstractA possible model of the mechanism of enzyme induction is presented and discussed in the light of present experimental knowledge. The central assumption in this model is that induction brings about the conversion of an enzyme‐precursor resulting in liberation and activation of a preexisting enzyme‐forming system.
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BioScience, 1970
documented in which such multiple drug therapy has created problems. For example, a patient receiving barbiturates requires an increased dose of an anticoagulant to obtain the desired reduced clotting of blood. The reason for this effect is thought to stem from the barbiturateproduced stimulation of the metabolism of the anticoagulant.
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documented in which such multiple drug therapy has created problems. For example, a patient receiving barbiturates requires an increased dose of an anticoagulant to obtain the desired reduced clotting of blood. The reason for this effect is thought to stem from the barbiturateproduced stimulation of the metabolism of the anticoagulant.
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Dose‐dependent enzyme induction
Clinical Pharmacology & Therapeutics, 1973Administration of qUinalbarbitone, 100 mg nightly, caused a fall in steady‐state plasma warfarin concentration ranging from 5% to 64.5% in 6 patients. There was no correlation between the extent of this fall and either the plasma concentration of quinalbarbitone or the initial rate of warfarin metabolism.
Alasdair Breckenridge +4 more
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The initial kinetics of enzyme induction
Biochimica et Biophysica Acta, 1961Abstract Kinetics of induction of several enzymes of Escherichia coli have been investigated under conditions where non-specific nutrient effects and permeability mechanisms are not important. Measurements made over time intervals of a few minutes permitted detection of initial events brought about by addition or removal of inducers or inhibitors ...
Louise S. Prestidge, Arthur B. Pardee
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Enzyme inhibition and induction
Anaesthesia & Intensive Care Medicine, 2008Abstract Enzymes fulfil the role of biological catalysts. One important family of enzymes in medicine and anaesthesia is the cytochrome P450 superfamily, which are involved in the metabolism of drugs. Although enzymes are recovered unchanged at the end of a reaction, their function can be inhibited or induced, which causes alterations in their ability
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Annual Review of Plant Physiology, 1971
The study of enzyme induction seeks to determine the factors controlling the appearance of specific enzyme proteins and to ascertain those parameters that influence the level of enzyme content. Molecular information in this area is currently available primarily from studies of bacterial and mam malian systems. Consequently, the plan is to first review
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The study of enzyme induction seeks to determine the factors controlling the appearance of specific enzyme proteins and to ascertain those parameters that influence the level of enzyme content. Molecular information in this area is currently available primarily from studies of bacterial and mam malian systems. Consequently, the plan is to first review
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Enzyme Induction in the Process of Development
1975The maintenance of homeostasis is necessary for normal growth. Before birth, the mother bears much of the responsibility for maintaining the constancy of the internal environment. Nutrients cross the placenta to the foetus, and waste products pass in the opposite direction.
J. W. T. Dickerson, T. K. Basu
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Enzyme induction and inhibition
1983The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of elimination. The rate of elimination of many drugs is governed largely by the rate of metabolism, and, therefore, any change in the activity of the drug-metabolizing enzymes may result in a ...
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