Results 171 to 180 of about 631,762 (309)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Efficient Expression of Lactone Hydrolase Cr2zen for Scalable Zearalenone Degradation in <i>Pichia pastoris</i>. [PDF]

Toxins (Basel)
Ahmad M, Wang H, Liu X, Wang S, Yin T, Deng K, Lu C, Zhang X, Jiang W.   +8 more
europepmc   +1 more source

Apoptosis and Autophagy Induction in Mammalian Cells by Small Interfering RNA Knockdown of mRNA Capping Enzymes

, 2008
Chun Chu, Aaron J. Shatkin
openalex   +1 more source

Key Enzymes of Triterpenoid Saponin Biosynthesis and the Induction of Their Activities and Gene Expressions in Plants [PDF]

, 2010
Chang Ling Zhao, Xiu Ming Cui, Yan Ping Chen, Liang Quan   +3 more
openalex   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Study on the High-Efficiency Expression of Horseradish Peroxidase in <i>Pichia pastoris</i>. [PDF]

Molecules
Wang Y, Jing Y, Li W, Wang Y, Li F, Qiu Y, Rao B.   +6 more
europepmc   +1 more source

Chimeric mice with humanized livers: a unique tool for in vivo and in vitro enzyme induction studies. [PDF]

Int J Mol Sci, 2013
Kakuni M, Yamasaki C, Tachibana A, Yoshizane Y, Ishida Y, Tateno C.   +5 more
europepmc   +1 more source

Machine Learning on Toxicogenomic Data Reveals a Strong Association Between the Induction of Drug-Metabolizing Enzymes and Centrilobular Hepatocyte Hypertrophy in Rats

Keiko Ikoma, Takuomi Hosaka, Akira Ooka, Ryota Shizu, Kouichi Yoshinari   +4 more
openalex   +2 more sources

Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite

, 2008
HX Zheng, Yong Huang, L A Frassetto, LZ Benet   +3 more
openalex   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source