Results 211 to 220 of about 636,727 (264)
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Dose‐dependent enzyme induction
Clinical Pharmacology & Therapeutics, 1973Administration of qUinalbarbitone, 100 mg nightly, caused a fall in steady‐state plasma warfarin concentration ranging from 5% to 64.5% in 6 patients. There was no correlation between the extent of this fall and either the plasma concentration of quinalbarbitone or the initial rate of warfarin metabolism.
A, Breckenridge +4 more
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Enzyme induction and inhibition
Pharmacology & Therapeutics, 1990The rate and extent of drug metabolism significantly influences drug effect. Enzyme induction by increasing the metabolism of drugs may result in important drug interactions. Other implications of enzyme induction include alterations in the metabolism of endogenous substrates, vitamins and activity of extrahepatic enzyme systems. Similarly a wide range
M, Barry, J, Feely
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Enzyme induction by oral testosterone
Clinical Pharmacology & Therapeutics, 1976Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half‐life had decreased significantly from 8.0 ± 2.7 to 5.7 ± 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty‐first day of testosterone ingestion than on the first day ...
S G, Johnson +3 more
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Enzyme patterns during bone induction
Calcified Tissue Research, 1970The results are as yet preliminary. The tendency for quantitative variation is given in Fig. 1 and the relative variation in isoenzyme pattern of LDH in Fig. 2. LDH activity increased parallel with increased level of metabolism and had a marked activity located to osteoblasts when new bone formation started.
K, Buring, H, Semb
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Enzyme Induction: Rifampin-Disopyramide Interaction
DICP, 1990A 62-year-old woman with a history of supraventricular tachycardia, paroxysmal atrial tachycardia, and premature ventricular contractions was admitted with palpitations and anxiety. Previous therapy with antiarrhythmics had resulted in intolerable adverse effects or no effect on the arrhythmia.
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Clinical Implications of Enzyme Induction
1975The implications of enzyme induction extend beyond alterations in rates of hepatic microsomal drug oxidation. In the last few years it has been shown in man that administration of inducing agents may be associated with increased turnover of endogenous substrates such as cholesterol, vitamin D and Cortisol, with alterations in liver blood flow and bile ...
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Enzyme Induction in Microbial Organisms
1975The de novo biosynthesis of certain enzymes of a microbial cell involved in catabolism of, for example, disaccharides, are subject to a switch-on mechanism elicited by a corresponding component of the surrounding medium. Such a component is by definition an inducer for the corresponding enzymes, which classically are responsible for the uptake and ...
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Loop dynamics and the evolution of enzyme activity
Nature Reviews Chemistry, 2023Marina Corbella Morató +2 more
exaly