Results 211 to 220 of about 641,868 (263)
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Trans-synaptic enzyme induction
Life Sciences, 1974Publisher Summary This chapter discusses the trans-synaptic enzyme induction. The increase in tyrosine hydroxylase synthesis is not a manifestation of a general increase in protein synthesis in the adrenergic neuron because under experimental conditions leading to a 2- to 3-fold increase in tyrosine hydroxylase activity, there was no detectable ...
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Dose‐dependent enzyme induction
Clinical Pharmacology & Therapeutics, 1973Administration of qUinalbarbitone, 100 mg nightly, caused a fall in steady‐state plasma warfarin concentration ranging from 5% to 64.5% in 6 patients. There was no correlation between the extent of this fall and either the plasma concentration of quinalbarbitone or the initial rate of warfarin metabolism.
A, Breckenridge +4 more
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Enzyme Induction by Enflurane in Man
Anesthesiology, 1976Concentrations of 6-beta-hydroxycortisol (6-OHF), a polar metabolite of cortisol formed in the endoplasmic reticulum (microsomes) of the liver, and 17-hydroxycorticosteroids (17-OHCS) were measured in the urines of six healthy adult male volunteers exposed to a mean of 9.6 MAC-hours of enflurane anesthesia as an index of possible enzyme induction.
M L, Berman +4 more
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The initial kinetics of enzyme induction
Biochimica et Biophysica Acta, 1961Abstract Kinetics of induction of several enzymes of Escherichia coli have been investigated under conditions where non-specific nutrient effects and permeability mechanisms are not important. Measurements made over time intervals of a few minutes permitted detection of initial events brought about by addition or removal of inducers or inhibitors ...
A B, PARDEE, L S, PRESTIDGE
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Mechanisms of hormonal induction of enzymes
Metabolism, 1973Abstract The study of enzyme induction by hormones has provided an important experimental model for the investigation of both the molecular mechanisms of hormone action as well as the regulation of specific gene expression in higher organisms. The exact mechanisms by which hormones induce enzymes are as yet unknown.
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Induction of the Drug-Metabolizing Enzymes
1975The deactivation of drugs and detoxication of environmental chemicals is brought about by the metabolism of these xenobiotics by enzymes, found primarily in the liver, which decrease the lipid-solubility of these compounds and facilitate their excretion (Parke, 1968).
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Enzyme Induction in the Process of Development
1975The maintenance of homeostasis is necessary for normal growth. Before birth, the mother bears much of the responsibility for maintaining the constancy of the internal environment. Nutrients cross the placenta to the foetus, and waste products pass in the opposite direction.
J W, Dickerson, T K, Basu
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Clinical Implications of Enzyme Induction
1975The implications of enzyme induction extend beyond alterations in rates of hepatic microsomal drug oxidation. In the last few years it has been shown in man that administration of inducing agents may be associated with increased turnover of endogenous substrates such as cholesterol, vitamin D and Cortisol, with alterations in liver blood flow and bile ...
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Enzyme Induction in Microbial Organisms
1975The de novo biosynthesis of certain enzymes of a microbial cell involved in catabolism of, for example, disaccharides, are subject to a switch-on mechanism elicited by a corresponding component of the surrounding medium. Such a component is by definition an inducer for the corresponding enzymes, which classically are responsible for the uptake and ...
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