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Toxicologic Pathology, 2010
Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal ...
Robert R, Maronpot +7 more
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Hepatic enzyme induction is generally an adaptive response associated with increases in liver weight, induction of gene expression, and morphological changes in hepatocytes. The additive growth and functional demands that initiated the response to hepatic enzyme induction cover a wide range of stimuli including pregnancy and lactation, hormonal ...
Robert R, Maronpot +7 more
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Journal of Steroid Biochemistry, 1983
The injection of estrogen into an immature or ovariectomized rat results in an increase in the specific activities of many uterine enzymes which can be detected, usually, within hours to days. The recent identification of the "estrogen-induced protein" as the brain type isozyme of creatine kinase (CKBB), provided an easily measurable enzyme marker, the
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The injection of estrogen into an immature or ovariectomized rat results in an increase in the specific activities of many uterine enzymes which can be detected, usually, within hours to days. The recent identification of the "estrogen-induced protein" as the brain type isozyme of creatine kinase (CKBB), provided an easily measurable enzyme marker, the
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Trans-synaptic enzyme induction
Life Sciences, 1974Publisher Summary This chapter discusses the trans-synaptic enzyme induction. The increase in tyrosine hydroxylase synthesis is not a manifestation of a general increase in protein synthesis in the adrenergic neuron because under experimental conditions leading to a 2- to 3-fold increase in tyrosine hydroxylase activity, there was no detectable ...
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Clinical Implications of Enzyme Induction and Enzyme Inhibition
Clinical Pharmacokinetics, 1981The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of elimination. The rate of elimination of many lipophilic drugs is governed by the activity of the hepatic microsomal mixed-function oxidases.
B K, Park, A M, Breckenridge
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Enzyme induction by oral testosterone
Clinical Pharmacology & Therapeutics, 1976Six normal male volunteers ingested a dose of 400 mg free testosterone daily as tablets over 21 days. By the end of treatment intravenous antipyrine half‐life had decreased significantly from 8.0 ± 2.7 to 5.7 ± 2.6 hr. The subjects eliminated testosterone from serum more rapidly on the twenty‐first day of testosterone ingestion than on the first day ...
S G, Johnson +3 more
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Dose‐dependent enzyme induction
Clinical Pharmacology & Therapeutics, 1973Administration of qUinalbarbitone, 100 mg nightly, caused a fall in steady‐state plasma warfarin concentration ranging from 5% to 64.5% in 6 patients. There was no correlation between the extent of this fall and either the plasma concentration of quinalbarbitone or the initial rate of warfarin metabolism.
A, Breckenridge +4 more
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Mechanisms of hormonal induction of enzymes
Metabolism, 1973Abstract The study of enzyme induction by hormones has provided an important experimental model for the investigation of both the molecular mechanisms of hormone action as well as the regulation of specific gene expression in higher organisms. The exact mechanisms by which hormones induce enzymes are as yet unknown.
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Induction of the Drug-Metabolizing Enzymes
1975The deactivation of drugs and detoxication of environmental chemicals is brought about by the metabolism of these xenobiotics by enzymes, found primarily in the liver, which decrease the lipid-solubility of these compounds and facilitate their excretion (Parke, 1968).
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Clinical Implications of Enzyme Induction
1975The implications of enzyme induction extend beyond alterations in rates of hepatic microsomal drug oxidation. In the last few years it has been shown in man that administration of inducing agents may be associated with increased turnover of endogenous substrates such as cholesterol, vitamin D and Cortisol, with alterations in liver blood flow and bile ...
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