Results 161 to 170 of about 971,704 (261)

Phytochemical Composition and Bioactivity of <i>Acanthus dioscoridis</i> var. <i>perringii</i>: An Integrated Analysis of Antioxidant Activity, Enzyme Inhibition, and Phenolic-Bioactivity Correlations. [PDF]

Pharmaceuticals (Basel)
Selvi B.
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Antidiabetic Potential of Sea Urchin Tripneustes gratilla Nanosuspension Based on In Vitro Enzyme Inhibition, In Vivo Evaluation, and Chemical Profiling Approaches. [PDF]

Curr Issues Mol Biol
Aljohani AKB, Alharbi AS, Alhazmi AB, Hudhayri MN, Almuwallad IB, Alhazmi MA, Almohammadi SM, Alsaleh AI, Aldhafiri A, Eltahir HM, Abouzied MM, Alrbyawi H, Mohamed MS, Abdel-Emam MM, Abdelkarem FM.   +14 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Targeting Oxalate Production by Combining Enzyme Inhibition and Proteolysis Activation: A Novel Therapeutic Approach for Primary Hyperoxaluria Type 1. [PDF]

J Med Chem
Arias F, Rohilla S, Sixto-López Y, Richard KSE, Das S, Anand SK, Luque-Navarro PM, Bañuelos-Sanchez G, Pacheco-García JL, Gade R, McKinney MP, Kumar D, Maxie J, Corr WR, Pandey N, Kaur H, Ding J, Tan L, Scott E, Nam H, Gottlieb E, Orr AW, Dhanesha N, Yurdagul A, Pey AL, Franco-Montalbán F, Gómez Vidal JA, Rom O, Díaz-Gavilán M.   +28 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Phytoconstituents, antioxidant and enzyme inhibition activities of coffee beans through widely targeted metabolomes and <i>in vitro</i> arrays. [PDF]

Food Chem X
Wang Y, Huang Z, He H, Zhou X, Yang D, Shu P, Chen X, Cheng J, Ma Y.   +8 more
europepmc   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Comparative Evaluation of the Digestive Enzyme Inhibition, Protein, and Starch Components of Ten <i>Macrotyloma uniflorum</i> (Lam.) Verdc. Accessions. [PDF]

Plants (Basel)
Ogunniyi QA, Molokwu AF, Nkumah AO, Adegoke AA, Oyatomi OA, Ogbole OO, Odeku OA, Fettke J, Abberton MT.   +8 more
europepmc   +1 more source

Inhibition of lysosomal enzymes by dapsone

British Journal of Dermatology, 1975
P D, Mier, J J, van den Hurk
openaire   +2 more sources