Results 261 to 270 of about 1,038,872 (308)

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management. [PDF]

Front Pharmacol
Eitah HE, Sayed RH, Maklad YA, Gamal El Din AA, Mahmoud K, El-Sahar AE, Alhejely A, Abdulbaqi AA, Naeim Attia H.   +8 more
europepmc   +1 more source

DNA‐Templated 2D Heterostructures as Phototriggered Dynamic Nanohybrids: From Releasing Molecular Loads to Controlling Enzyme Biocatalytic Function

Advanced Functional Materials, EarlyView.
DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen, Haosen Miao, Weiying Hong, Matteo Palma   +3 more
wiley   +1 more source

Human Gut Bacteria and Lipidic Nanoparticles: Particle Composition Predicts Structural Transformation and Bacterial Biocompatibility

Advanced Functional Materials, EarlyView.
Lipidic nanoparticles (LNPs) were incubated with 21 gut bacteria frequently associated with the human microbiome. SAXS revealed that ∼75% of tested species induced structural transformations in monoolein LNPs, whereas phytantriol and phospholipid formulations remained unaffected.
Jonathan Caukwell, Emily L. Gulliver, Livia Salvati Manni, Frithjof Herb, Caitlin Welsh, Samuel C. Forster, Andrew J. Clulow, Wye‐Khay Fong   +7 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

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ENZYME INHIBITION BY ANTIBODIES

Acta Endocrinologica, 1975
ABSTRACT The interest in the inhibition of enzymes by their specific antibodies stems mainly from the fact that these systems can serve as suitable models in the study of neutralization of biologically active molecules in general. The interaction of enzymes with their specific antibodies generally leads to a reduction in their enzymatic ...
openaire   +2 more sources

Inhibition of enzymes by lipoproteins

Biochimica et Biophysica Acta, 1956
Abstract 1. 1. Experiments designed to test the specificity of lipoproteins as inhibitors of glucose utilisation are presented. 2. 2. It has been shown that the difference between normal and diabetic plasma in regard to content of this material is largely quantitative. 3. 3.
openaire   +2 more sources

Diagnosis of enzyme inhibition based on the degree of inhibition

Biochimica et Biophysica Acta (BBA) - General Subjects, 2003
In this work, a method for the diagnosis of kinetic inhibition, based on the dependence of the degree of inhibition (epsilon(i)) on the inhibitor concentration [I] and on the substrate concentration [S], is presented. Because the degree of inhibition is a ratio between rates, kinetic data are normalized by the introduction of an internal control-the ...
Antunes, Fernando, Marinho, Helena Susana, Barreto, Maria do Carmo, Pavão, Maria Leonor, Pinto, Ruy Eugénio   +4 more
openaire   +3 more sources

Clinical Implications of Enzyme Induction and Enzyme Inhibition

Clinical Pharmacokinetics, 1981
The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of elimination. The rate of elimination of many lipophilic drugs is governed by the activity of the hepatic microsomal mixed-function oxidases.
B K, Park, A M, Breckenridge
openaire   +2 more sources

Angiotensin converting enzyme inhibition and renin inhibition

Journal of Hypertension, 1989
Over a period of several years, methods of measuring circulating angiotensin II have been progressively improved and it has now become possible to measure circulating angiotensin II with a high degree of accuracy. The main ingredients in this new methodology are bonded-phase silica for quantitative angiotensin extraction from biological fluids and ...
Nussberger J, Waeber B, Brunner HR
openaire   +3 more sources

Cyclooxygenase enzymes: catalysis and inhibition

Current Opinion in Structural Biology, 2001
Scientists working in the field of cyclooxygenase enzymes have witnessed several major advances in the past two years. Crystal structures of fatty acid substrate and prostaglandin product complexes have been elucidated. Elegant site-directed mutagenesis studies have pinpointed the roles of key amino acids within the active site. Together, these results
R G, Kurumbail, J R, Kiefer, L J, Marnett   +2 more
openaire   +2 more sources