Results 1 to 10 of about 517,918 (147)

Biochemical characterization and identification of ferulenol and embelin as potent inhibitors of malate:quinone oxidoreductase from Campylobacter jejuni

Frontiers in Molecular Biosciences, 2023
Campylobacter jejuni infection poses a serious global threat to public health. The increasing incidence and antibiotic resistance of this bacterial infection have necessitated the adoption of various strategies to curb this trend, primarily through ...
Augustin Tshibaka Kabongo, Augustin Tshibaka Kabongo, Augustin Tshibaka Kabongo, Rajib Acharjee, Rajib Acharjee, Rajib Acharjee, Takaya Sakura, Takaya Sakura, Gloria Mavinga Bundutidi, Gloria Mavinga Bundutidi, Gloria Mavinga Bundutidi, Gloria Mavinga Bundutidi, Endah Dwi Hartuti, Endah Dwi Hartuti, Endah Dwi Hartuti, Cadi Davies, Ozan Gundogdu, Kiyoshi Kita, Kiyoshi Kita, Kiyoshi Kita, Tomoo Shiba, Daniel Ken Inaoka, Daniel Ken Inaoka, Daniel Ken Inaoka   +23 more
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Tyrosine Hydroxylase and DOPA Decarboxylase Are Associated With Pupal Melanization During Larval–Pupal Transformation in Antheraea pernyi

Frontiers in Physiology, 2022
In insects, melanism plays important roles in defense, immunoreactions, and body color. The underlying molecular mechanisms of melanism in different insects are diverse and remain elusive.
Qi Wang, Liang Zhong, Yong Wang, Shengwei Zheng, Yumeng Bian, Junhao Du, Ruisheng Yang, Wei Liu, Li Qin   +8 more
doaj   +1 more source

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors

Frontiers in Chemistry, 2022
A series of benzylidene analogs of oleanolic acid 4a∼4s were synthesized and assessed for their α-glucosidase and α-amylase inhibitory activities. The results presented that all synthesized analogs exhibited excellent-to-moderate inhibitory effects on α ...
Jun-Jie Ke, Jing Lin, Xin Zhang, Xiao-Zheng Wu, Ying-Ying Zheng, Chun-Mei Hu, Yu Kang, Kun Zhang, Zhuang Xiong, Zhi-Qiang Ma   +9 more
doaj   +1 more source

Synthesis and Evaluation of Coumarin-Chalcone Derivatives as α-Glucosidase Inhibitors

Frontiers in Chemistry, 2022
Coumarin and chalcone, two important kinds of natural product skeletons, both exhibit α-glucosidase inhibitory activity. In this work, coumarin-chalcone derivatives 3 (a∼v) were synthesized, and their α-glucosidase inhibitory activity was screened.
Chun-Mei Hu, Yong-Xin Luo, Wen-Jing Wang, Jian-Ping Li, Meng-Yue Li, Yu-Fei Zhang, Di Xiao, Li Lu, Zhuang Xiong, Na Feng, Chen Li   +10 more
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Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle

Plants, 2022
Mentha spicata is one of the most popular species in the genus, and it is of great interest as a gastrointestinal and sedative agent in the folk medicine system. In this study, different M.
Gokhan Zengin, Gunes Ak, Ramazan Ceylan, Sengul Uysal, Eulogio Llorent-Martínez, Simonetta Cristina Di Simone, Monica Rapino, Alessandra Acquaviva, Maria Loreta Libero, Annalisa Chiavaroli, Lucia Recinella, Sheila Leone, Luigi Brunetti, Amelia Cataldi, Giustino Orlando, Luigi Menghini, Claudio Ferrante, Marwa Balaha, Viviana di Giacomo   +18 more
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Research on Diffusible Signal Factor-Mediated Quorum Sensing in Xanthomonas: A Mini-Review

Molecules, 2023
Xanthomonas spp. are important plant pathogens that seriously endanger crop yields and food security. RpfF is a key enzyme that is involved in the synthesis of diffusible signal factor (DSF) signals and predominates in the signaling pathway regulating ...
Yu-Mei Feng, Zhou-Qing Long, Hong-Mei Xiang, Jun-Ning Ran, Xiang Zhou, Song Yang   +5 more
doaj   +1 more source

Rutin, A Natural Inhibitor of IGPD Protein, Partially Inhibits Biofilm Formation in Staphylococcus xylosus ATCC700404 in vitro and in vivo

Frontiers in Pharmacology, 2021
Staphylococcus xylosus (S. xylosus) has become an emerging opportunistic pathogen due to its strong biofilm formation ability. Simultaneously, the biofilm of bacteria plays an important role in antibiotic resistance and chronic infection.
Qianwei Qu, Wenqiang Cui, Wenqiang Cui, Xiaoxu Xing, Rongfeng Zou, Xingyu Huang, Xiaozhen Wang, Tong Wu, God’spower Bello-Onaghise, God’spower Bello-Onaghise, Shuguang Yuan, Yanhua Li   +11 more
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Extracts of Fruits and Plants Cultivated In Vitro of Aristotelia chilensis (Mol.) Stuntz Show Inhibitory Activity of Aldose Reductase and Pancreatic Alpha-Amylase Enzymes

Plants, 2022
Aristotelia chilensis is a plant whose fruit is considered a powerful natural antioxidant. During the last years, some investigations of the fruit have been carried out, finding antioxidant properties in the juice or the phenolic fraction.
Adriana Pineda, Andrea Arenas, Juan Balmaceda, Gustavo E. Zúñiga   +3 more
doaj   +1 more source

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile [PDF]

, 2016
Factor XIIIa (FXIIIa) is a transglutaminase that catalyzes the last step in the coagulation process. Orthostery is the only approach that has been exploited to design FXIIIa inhibitors.
Afosa, Daniel K., Al-Horani, Rami A., Desai, Umesh R., Karuturi, Rajesh, Lee, Michael   +4 more
core   +8 more sources

Perspective on the Structural Basis for Human Aldo-Keto Reductase 1B10 Inhibition

Metabolites, 2021
Human aldo-keto reductase 1B10 (AKR1B10) is overexpressed in many cancer types and is involved in chemoresistance. This makes AKR1B10 to be an interesting drug target and thus many enzyme inhibitors have been investigated.
Francesc Xavier Ruiz, Xavier Parés, Jaume Farrés   +2 more
doaj   +1 more source